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What is Aciclovir AL and what it is used for
Aciclovir AL is a medicinal product for the treatment of viral infections
Acyclovir AL is used in:
• Nerpes zoster to prevent severe cases of herpes simplex viral infections in patients with a suppressed immune system exposed to an increased risk of infections, eg after organ transplantation.
2. Before you take Aciclovir AL
Do not take Aciclovir AL if you are:
• Hypersensitivity to aciclovir or any of the other ingredients of the medicinal product.
• If you have kidney function abnormalities or decreased urine production (less than 100 ml urine per day), you should not use aciclovir for prophylaxis as there is no data on the use of aciclovir tablets under these conditions.
Take special care with Aciclovir AL
What you should be aware of when you decide to use this medicine in elderly people:
Elderly patients more often suffer from kidney failure. For this reason, it is advisable to monitor renal function in this age group and to increase the amount of fluids when taking the Aciclovir AL tablets. The treating physician will determine the appropriate dosage (see "How to take Aciclovir ALL").
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Which other medicines are known to affect the effect of Aciclovir AL
Probenecid (a uricosuric acid for lowering uric acid in the blood) reduces the release of Aciclovir AL through the kidneys, which may lead to prolongation of aciclovir downtime in the body.
Probenecid and cimetidine increase the plasma concentration of aciclovir and decrease its secretion by the kidneys. Higher plasma concentrations of aciclovir have been observed when mycophenolate mofetil (a medicine that suppresses the normal immune function of the body) is administered with aciclovir rather than with aciclovir alone. However, the dosage adjustment due to the broad therapeutic index of aciclovir is not necessary. No significant increase in toxicity was observed in patients undergoing antiretroviral, oral (Zidovudine) therapy with concomitant use of aciclovir.
Pregnancy and breastfeeding
The physician should carefully assess the relationship between the expected benefit and the potential risk in pregnant women who require treatment with Aciclovir AL. Aciclovir is found in breast milk after taking aciclovir tablets. Therefore, breast-feeding should be discontinued while receiving aciclovir tablets.
Driving and using machines
No direct effect of aciclovir on the ability to react and drive is known. However, it should be remembered that rare side effects such as drowsiness, vertigo and hallucinations may occur, especially in patients with impaired renal function.
3. How to take Aciclovir AL
Always take Aciclovir AL exactly as prescribed by your doctor. If you have any doubts and questions, ask your doctor or pharmacist.
Dosage and administration, duration of therapy:
These instructions apply only if your doctor has not prescribed anything other than the medicine Aciclovir AL. Please comply with the instructions for use or those given by your doctor, as otherwise Acyclovir AL will not have the necessary effect and safety.
In what quantities and how often should you take Aciclovir Al tablets?
2 tablets Aciclovir (800 mg) 5 times a day every 4 hours a day.
For the prevention of infections caused by herpes simplex virus:
One tablet of Aciclovir (400 mg) 4 times a day every 6 hours can be prescribed in patients with a severely suppressed immune system exposed to an increased risk of infections, After organ transplantation.
PATIENTS WITH REMOVAL FAILURE:
Patients with abnormal renal function, especially in the elderly, may need a reduced dosage of aciclovir as shown above. In kidney abnormalities
Function, the treating physician will determine the appropriate dosage depending on the renal function (see below):
How and when to take Aciclovir AL
Tablets should be taken after a meal with a sufficient amount of liquid (eg a glass of water).
Increased amount of fluid should be taken with the use of Aciclovir AL tablets, especially in patients with impaired renal function.
To achieve good results, treatment with Aciclovir AL should begin immediately with the onset of the first symptoms of infection.
Especially in recurrent herpes simplex virus infections, Aciclovir AL should be initiated at the first symptoms of the new infection (itching, discomfort, first
How long can you take Aciclovir AL
The duration of treatment will be decided by your doctor. For infections caused by herpes zoster virus, the duration of treatment with Aciclovir AL is usually 5-7 days, but the clinical condition in some patients may require longer treatment.
The duration of prophylaxis for herpes simplex virus infections in and patients with suppressed immune protection depends on the degree of immune suppression and must be decided individually by the treating physician.
If you exceed the dose of Aciclovir AL (a specific or accidental overdose of this medicine).
No poisoning should be expected when Aciclovir AL is overdosed. No symptoms of poisoning occur in a single dose of 5 g acyclovir. There is no evidence of single doses of higher doses. In case of overdosage and worsening of the side effects or if you have any of these concerns, talk to your doctor.
If you forget to take or take less than the prescribed amount of Aciclovir AL
Do not take a double dose of Aciclovir AL tablets at the next dose and continue treatment as prescribed by your doctor.
If you have missed more than one dose or have taken less than the prescribed amount, talk to your doctor.
If you stop taking Aciclovir ALL
Even if the condition improves, the dose of Aciclovir AL should be continued as prescribed by your doctor to ensure the success of the treatment. If you have any unusual side effects, talk to your doctor before stopping or stopping treatment early.
4. Possible side effects
What side effects may occur with Aciclovir AL
Like other medicines, Aciclovir AL can cause side effects, although they do not occur in any patient treated with this medicine.
For the assessment of side effects, the following classification based on their frequency was used:
Very common: In more than 1 in 10 patients treated
Common: In less than 1 in 10 but more than 1 in 100 treated patients
Uncommon: In less than 1 in 100 but more than 1 in 1,000 treated patients
Rare: Less than 1 in 1000 but more than 1 in 10,000 treated patients
Very rare: Less than 1 in 10,000 patients treated, including isolated cases
Not known: The available data can not be estimated
Blood and lymphatic system disorders:
Very rare: Anemia, leucopenia, thrombocytopenia.
Immune system disorders:
Rare: Anaphylaxis (rapid-type allergic reaction, manifested by redness, itching, edema, shock).
Psychiatric disorders and nervous system disorders:
Common: Headache, dizziness
Very rare: Agitation, confusion, tremor (trembling, involuntary, rapid alternating contraction and relaxation of muscles.), Ataxia (inability to coordinate muscle activity when performing voluntary movements}, dysarthria (difficulty speaking, impairs delivery of sounds ), hallucinations, psychotic symptoms, convulsions, somnolence, encephalopathy (disorders of the brain, metabolic, degenerative), coma. The above-mentioned adverse reactions are usually reversible and is reported primarily in patients with renal impairment or etc. that there are other predisposing factors.
Respiratory, thoracic and mediastinal disorders:
Rare: Dyspnoea (shortness of breath, difficulty in breathing).
Common: Nausea, vomiting, diarrhea, abdominal pain.
Hepatobiliary (liver and bile) disorders:
Rare: Reversible increases in bilirubin and hepatic enzymes
Very rare: Hepatitis (jaundice).
Skin and subcutaneous tissue disorders:
Common: pruritus, rash (including photosensitivity).
Uncommon: Urticaria (rash). Increased diffuse hair loss. This process is associated with a number of diseases and drugs, and the association with aciclovir is unclear.
Rare: Angioedema (a specific allergic reaction characterized by swelling of the face, lips, eyelids).
Renal and urinary disorders:
Rare: Increase in blood urea and creatinine.
Very rare: Acute kidney failure.
General disorders and administration site conditions:
Common: fatigue, fever.
What measures should you take in case of side effects?
If any of the side effects listed in this leaflet become serious or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Shelf life is printed on the box and blister. Do not use after expiration date. The expiry date refers to the last day of the observed month.
5. How to store Aciclovir AL
Keep out of the reach and sight of children!
6. Additional Information
What does the pack of Aciclovir AL contain?
1 tablet contains:
Active substance: Aciclovir 400 mg
Excipients: Microcrystalline cellulose, copovidone, magnesium stearate, sodium starch glycolate, silicon dioxide.
Original pack of 35 tablets.
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