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What Co-Prenessa is and what it is used for
What is Co-Prenessa
Co-Preneasa is a combination of two active ingredients, perindopril and indapamide. Co-Transferase is an antihypertensive medicine and is used to treat high blood pressure (hypertension).
What is Co-Prenessa used for?
Perindopril belongs to a class of medicines called angiotensin converting enzyme inhibitors (ACE inhibitors). They act by expanding the blood vessels, which makes it easier to pump blood from the heart through them. Indapamide is a diuretic. Diuretics increase the amount of urine released by the kidneys. Indapamide, however, differs from other diuretics, as it causes a slight increase in the amount of urine released. Each of the active substances lowers blood pressure and they work together to control your blood pressure.
Co-Transferase 8 mg / 2.5 mg is indicated for patients who receive separate 8 mg perindopril tablets and 2.5 mg indapamide. Instead, these patients may receive one Co-Transferase 8 mg / 2.5 mg tablet containing the two active substances.
2. What do you need to know before taking Co-Prenessa
Do not take Co-Prenessa
if you are allergic to perindopril or other ACE inhibitors; either to indapamide or to other sulphonamides or to any of the other ingredients of this medicine (listed in section 6);
if you have experienced symptoms such as whistling, facial or tongue swelling, severe pruritus, or severe skin rashes in pretreatment with an ACE inhibitor or if you or a member of your family had such symptoms in other circumstances (a condition called angioneurotic edema),
if you have severe liver disease or suffer from a condition called hepatic encephalopathy (degenerative brain disease), if you have severe and moderate kidney disease, or if you are on dialysis treatment if you have low or high potassium levels in the blood,
if you are suffering from untreated decompensated heart failure (symptoms may include severe fluid retention and breathing difficulties) if you are pregnant after the 3rd month (also, it is best to avoid Co-Precessa at the beginning of pregnancy - see "Pregnancy and breast-feeding") if you are breast-feeding,
if you have diabetes or have impaired kidney function and are being treated with a medicine to lower blood pressure containing aliskiren.
Warnings and precautions
Talk to your doctor or pharmacist before taking Co-Transfer:
if you have aortic stenosis (narrowing of the main blood vessel coming out of the heart) or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood)
if you have any other heart or kidney problems,
if you have liver problems,
if you suffer from connective tissue disorders (skin disease) such as systemic lupus erythematosus (a form of chronic inflammation) or scleroderma,
if you have atherosclerosis (hardening of the arteries),
if you suffer from hyperparathyroidism (a condition where the parathyroid glands do not function properly) if you suffer from gout if you have diabetes,
if you are on a diet with limited intake of salt or use salt substitutes that contain potassium,
if you are taking lithium or potassium-sparing diuretics (spironolactone, triamterene) as their use with Co-Transferus should be avoided (see section "Other medicines and Co-Transfer"),
if you are taking any of the following medicines used to treat high blood pressure: angiotensin II receptor blocker (ARB) (also known as sartans - for example, valsartan, telmisartan, irbesartan), especially if you have kidney problems associated with diabetes, aliskiren.
Your doctor may periodically check your kidney function, blood pressure and the amount of electrolytes (eg potassium) in your blood. Also see the information titled "Do not take Co-Transfer" if you are taking any of the following medicines, the risk of angioedema is increased:
(used to treat diarrhea), sirolimus, everolimus, temsirolimus and other medicines belonging to a class of medicines called mTOR inhibitors (used to avoid rejection of transplanted organs).
As with other angiotensin converting enzyme inhibitors, perindopril is less effective in lowering blood pressure in black patients than in non-black patients.
In black patients receiving ACE inhibitors, a higher incidence of angioedema has been reported than in other races.
Tell your doctor if you think you may become pregnant or are pregnant. Co-Prevensa is not recommended in early pregnancy and should not be taken if you are pregnant after the third month as it may cause serious harm to your baby if used during this period (see "Pregnancy and breast-feeding") .
Other Drugs and Co-Prenessa
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
You should avoid using Co-Precessa with: lithium (used to treat depression),
potassium sparing diuretics (spironolactone, triamterene) and potassium salts.
Treatment with Co-Transfer may be affected by other medicines. Be sure to tell your doctor if you are taking any of the following medicines, as special precautions may be necessary:
other medicines to treat high blood pressure, procainamide (to treat heart rhythm), allopurinol (for gout),
terfenadine, astemizole, mizolastine (antihistamine medicines to treat hay fever or allergies),
corticosteroids used to treat various conditions including severe forms of asthma and rheumatoid arthritis,
immunosuppressive agents that are used to treat autoimmune diseases or after transplantation to suppress the organ rejection reaction (eg cyclosporin),
medicines to treat cancer,
erythromycin for injection, moxifloxacin, sparfloxacin (antibiotics),
halofantrine (used to treat certain types of malaria), pentamidine (used to treat pneumonia),
vincamine (used to treat clinical cognitive impairment in elderly, including memory loss),
bepridil (used to treat a breast frog, angina),
medicines used for heart rhythm problems (eg quinidine, hydroquinidine, disopyramide, amiodarone, sotalol), digoxin or other cardiac glycosides (for the treatment of heart disease), baclofen (for the treatment of muscular rigidity occurring in diseases such as multiple sclerosis) ,
medicines for the treatment of diabetes, such as insulin or metformin,
calcium, including calcium supplements,
stimulating action laxatives (eg senna),
non-steroidal anti-inflammatory drugs (eg ibuprofen) or high doses
salicylates (e.g., aspirin),
amphotericin (for treating severe fungal infections), medicines to treat mental disorders such as depression, anxiety, schizophrenia (eg tricyclic antidepressants and neuroleptics (such as amisulpride, sulpiride, sulpridide, thiapride, haloperidol, droperidol), tetracoscid treatment of Crohn's disease),
(used to treat rheumatoid arthritis), medicines most commonly used to treat diarrhea (racemacotril) or to avoid rejection of transplanted organs (sirolimus, everolimus, temsirolimus and other medicines belonging to the class of medicinal products products called mTOR inhibitors). See section "Warnings and Precautions".
Your doctor may need to change your dose and / or take other precautions: if you are taking angiotensin II receptor blocker (ARB) or aliskiren (see also the information titled "Do not take Co-Transmission" and "Warnings and precautions" ).
Co-Prenessa with food and drink
It is preferable that Co-Precessa is taken before a meal.
Pregnancy and breastfeeding
If you are pregnant or are breast-feeding, think you may be pregnant or plan to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.
Tell your doctor if you are pregnant (or think you may become pregnant). Your doctor will usually advise you to stop taking Co-Precessa before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Co-Precessa. Co-Prevensa is not recommended in early pregnancy and should not be taken if you are pregnant after the third month as this may cause serious harm to your baby if used after the third month of pregnancy.
Tell your doctor if you are breast-feeding or think to start breast-feeding. Co-Prevensa is contraindicated in breast-feeding women and your doctor may choose another treatment for you if you want to breast-feed.
Driving and using machines
Co-Transferase usually does not affect attention, but some patients may experience various reactions such as dizziness or weakness associated with lowering of blood pressure. Your ability to drive or operate machinery may be impaired if you experience it.
Co-Prenessa contains lactose
If your doctor has told you that you have an intolerance to some sugars, contact him or her,
before using this medicine.
3. How do you take Co-Prenessa
Always take this medicine exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.
The usual dose is one tablet once a day.
Your doctor may decide to change the dosage regimen if you suffer from kidney failure.
It is preferable to take the tablets in the morning and before meals. Swallow the tablets with a glass of water.
If you take more Co-Precessa than you should
If you have taken too much tablets, contact your doctor immediately
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everyone gets them.
If you experience any of the following, stop using the medicine immediately and tell your doctor immediately: swelling of the face, lips, mouth, tongue or throat, difficulty in breathing, dizziness or fainting in the eyes, abnormally fast or irregular heartbeat.
In descending order of frequency, side effects may include:
Common (may affect up to 1 in 10 people):
headache, dizziness, dizziness, tingling of the limbs, visual disturbance, tinnitus (feeling of tinnitus), vision of light spots resulting from low blood pressure, cough, shortness of breath, gastrointestinal disorders (nausea , stomach pain, anorexia, vomiting, abdominal pain, altered taste, dry mouth, indigestion or difficulty in digestion, diarrhea, constipation), allergic reactions (such as skin rashes, pruritus), cramps,
Uncommon (may affect up to 1 in 100 people):
(such as difficulty in breathing, swelling of the face or tongue), urticaria, purpura (red spot rash), kidney problems, difficulty breathing, difficulty in breathing, impotence, sweating,
Rare (may affect up to 1 in 1,000 people):
increased calcium levels in plasma, worsening of psoriasis.
Very rare (may affect up to 1 in 10,000 people): confusion, cardiovascular disorders (irregular heartbeat, angina, infarction), eosinophil type pneumonia (rhinitis), rhinitis (stomach or runny nose) manifestations such as erythema multiforme. If you suffer from systemic lupus erythematosus (a type of collagenosis), worsening may occur. Cases of sensitivity to light (change in skin type) after sun exposure or artificial UVA rays have also been reported.
Not known (frequency can not be estimated from the available data):
seizures, irregular heart rhythm, potentially life-threatening (Torsade de pointes), abnormal electrocardiogram, elevated liver enzyme levels.
Blood, kidney, liver or pancreas abnormalities and changes in laboratory parameters (blood tests) may occur. Your doctor may need to appoint blood tests to track your condition. In cases of liver failure (liver problems) there is a possibility of developing hepatic encephalopathy (a degenerative brain disease).
How to Store Co-Prenessa
Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the carton and the blister. The expiry date refers to the last day of that month.
2 mg / 0.625 mg 4 mg / 1.25 mg
Store below 25 ° C.
Store in the original package in order to protect from moisture.
Store below 30 ° C.
Store in the original package in order to protect from moisture.
Do not dispose of medicines in the sewer or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What Co-Prenessa contains:
The active ingredients are tert-butylamine perindopril (perindopril tert-butylamine) and indapamide (indapamide).
Each tablet contains 2 mg of tert-butylamine perindopril equivalent to 1.67 mg, perindopril and 0.625 mg of indapamide.
Each tablet contains 4 mg of tert-butylamine perindopril, perindopril and 1.25 mg of indapamide.
Each tablet contains 8 mg of tert-butylamine perindopril, equivalent to 6.68 mg of perindopril and 2.5 mg of indapamide.
The other ingredients are calcium chloride hexahydrate, lactose monohydrate, crospovidone, microcrystalline cellulose, sodium hydrogen carbonate, colloidal anhydrous silica, magnesium stearate.
What does Co-Transfer and what does the package look like?
2 mg / 0.625 mg
This medicinal product is white to off-white, round, slightly biconvex tablets with bevelled edges, engraved with a short line on one side.
4 mg / 1.25 mg
This medicinal product is a white to off-white, round, slightly biconvex, scored on one side with bevelled edges. The divider is only for ease of breaking for easier swallowing, not for splitting in equal doses.
8 mg / 2.5 mg
This medicinal product is a white to off-white, round, slightly biconvex, scored tablet on one side. The divider is only for ease of breaking for easier swallowing, not for splitting in equal doses.
These tablets are available in cartons of 14, 20, 28, 30, 50, 56, 60, 90, 100 tablets in blisters. Not all pack sizes may be marketed.
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