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What is Flexistad 400 mg and what it is used for
Flexistad 400 mg is an anti-inflammatory and pain-relieving drug (non-steroidal anti-inflammatory). Flexix is used for the symptomatic treatment of pain and inflammation in:
Acute inflammation of the joints (acute arthritis), including gout attacks
Chronic inflammation of the joints (chronic arthritis), especially rheumatoid arthritis / chronic polyarthritis /
ankylosing spondylitis (Behterev's disease) and other inflammatory-rheumatoid diseases of the spine
inflammatory conditions in degenerative joint and vertebral diseases / osteoarthritis and spondyloarthrosis /
inflammatory rheumatic diseases of soft tissues
painful swelling and inflammation after injuries and injuries
2. What you need to know before taking Flextat 400 mg
Do not take Flexistad 400 mg if:
you are hypersensitive to the active substance or to any of the excipients of this medicine (listed in section 6);
if you have ever had difficulty in breathing (bronchospasm), asthma attacks, inflammation of the nasal mucosa or reactions after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs in the past;
if you have a history of recurrent stomach / duodenal ulcer (peptic ulcer) or bleeding (at least two different episodes of diagnosed ulcer or bleeding);
if you suffer from unclear haematopoiesis / blood circulation disorders;
if you suffer from gastrointestinal bleeding or perforation associated with previous treatment with non-steroidal anti-inflammatory drugs (NSAIDs);
if you suffer from cerebrovascular (cerebrovascular) or other active bleeding (bleeding);
in severe heart failure (myocardial ischemia);
in the last trimester of pregnancy;
in children and adolescents under 15 years of age.
Warnings and precautions
Check with your doctor or pharmacist before taking Flexstone.
The conditions listed below describe how you can take Flexxed under certain conditions with caution and caution (at longer dosing intervals or at a reduced dose and under medical supervision). Ask your doctor for advice. This also applies if you have had any of the listed conditions in the past.
The concomitant administration of Flexixa with other non-steroidal anti-inflammatory drugs (NSAIDs), including the so- inhibitors of cyclooxygenase (COX-2 inhibitors). Adverse reactions occur less frequently when the lowest effective dose is used for the shortest amount of time needed to control the symptoms.
In the elderly, the incidence of side effects, especially bleeding from the gastrointestinal tract and perforation, is higher and sometimes these side effects in the elderly may be fatal. Therefore, patients in this age group should be closely monitored.
Bleeding from the gastrointestinal tract, ulcers and perforation
Bleeding from the gastrointestinal tract, ulcers and perforation, in some cases fatal, have been reported with NSAIDs. These reactions may occur at any time during treatment, with or without warning symptoms or a history of serious gastrointestinal disease.
The risk of gastrointestinal bleeding, ulceration and perforation is higher at dose escalation and in patients who have had ulcers in the past, particularly ulcers, complications, bleeding and perforation (see section 2, "Do not take Flextastic"), and in elderly patients. Such patients should start treatment with the lowest effective dose.
Patients who are prescribed low-dose acetylsalicylic acid or other medicines known to cause gastrointestinal disorders should also be given concomitant medication (such as missoprostol or proton pump inhibitors ).
If you have experienced gastrointestinal side effects in the past, especially if you are elderly, you should report any abnormal abdominal symptoms (such as bleeding), especially if they occurred at the beginning of treatment.
If you take other medicines that may increase the risk of ulcer or bleeding, such as oral corticosteroids, anticoagulants (blood clotting-lowering drugs such as warfarin), selective serotonin reuptake inhibitors (used to treat depression and other psychiatric disorders) or inhibitors of platelet aggregation (for example, acetylsalicylic acid), your doctor should regularly monitor blood clotting to avoid potential bleeding em (see section 2, "Other medicines and Flexistad").
Treatment should be discontinued if you develop gastrointestinal bleeding or ulceration during treatment with Flexix.
NSAIDs should be used with caution in patients with gastrointestinal disorders or in case of doubt
Careful monitoring is required when:
in patients with gastrointestinal diseases or suspected gastrointestinal ulcers or chronic inflammatory bowel disease (ulcerative colitis, Crohn's disease), arterial hypertension (high blood pressure) and / or heart failure recently after major surgical interventions
if you have an allergy (for example, skin reactions related to the use of other medicines, asthma, hives), chronic nasal mucosal edema (nasal polyps), chronic obstructive airway diseases
severe impairment of renal or hepatic function
Very rarely, severe hypersensitivity reactions (eg anaphylactic shock) have been reported.
At the first signs of a severe hypersensitivity reaction after taking Flexistad, treatment should be stopped. Depending on the severity of the symptoms, treatment should be initiated by a specialist.
Ibuprofen, the active substance of Flexixad, can reduce blood platelet aggregation (clotting). Patients with blood clotting disorders should be closely monitored.
Prolonged treatment with Flexixta 400 mg requires regular monitoring of liver and kidney function as well as blood counts.
Check with your doctor or dentist if you have been taking Flexixa before surgery.
Prolonged intake of high doses of the painkiller may cause a headache that should not be treated with increased doses of this medicine.
Regular use of painkillers, especially when taking several analgesics in combination, can lead to permanent kidney damage at risk of kidney failure (analgesic-induced nephropathy).
Taking ibuprofen, like any drug that inhibits prostaglandin synthesis, can make pregnancy difficult. In case of such problems or if you are planning to become pregnant, tell your doctor.
Antiinflammatory / painkillers such as ibuprofen may be associated with a slight increase in the risk of heart attack or stroke, especially when used in high doses. Do not exceed the recommended dosage or duration of treatment.
You should discuss your treatment with your doctor or pharmacist before starting to take Flexistad
if you have heart problems including heart failure, angina pectoris or chest pain, bypass surgery, peripheral arterial disease (poor circulation in the legs or feet due to narrowed or blocked arteries) or any type of stroke (including microinvestigation or transient ischemic attack).
if you have high blood pressure, diabetes, high cholesterol, a family history of heart disease or stroke, or if you are a smoker.
Children and adolescents
Children and adolescents under 15 years should not use Flexix as the drug content is too high for this age group. Other forms of reduced drug substance concentration are suitable for this age group.
Other drugs and Flexistad
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Flexistad may affect or be affected by some other medicines.
Anti-clotting drugs (ie dilute blood / prevent clotting, eg aspirin / acetylsalicylic acid, warfarin, ticlopidine);
Medicines that lower high blood pressure (ACE inhibitors such as captopril, beta-blockers, atenolol-containing medicines, angiotensin II receptor antagonists such as losartan).
Concomitant administration of Flexixid with digoxin (a medicine used to enhance the heart), phenytoin (anticonvulsant medicine) or lithium (a medicine to treat manic mental disorders) can lead to an increase in serum concentrations of these drugs. Continuous control of the levels of lithium in the blood. Control of digoxin and phenytoin levels is recommended.
Flexistad 400 mg may reduce the action of diuretics and antihypertensive drugs (detoxifying tablets and blood pressure lowering medicines).
Flexistad 400 mg may reduce the effect of ACE inhibitors (used to treat heart failure and high blood pressure).
Concomitant use of these medicines may increase the risk of kidney function impairment.
Concomitant administration of Flexixad 400 mg and potassium-sparing disintegrating tablets (some diuretics) may lead to hyperkalaemia (increase in blood potassium concentration).
Concomitant administration of Flexixad 400 mg and other non-steroidal anti-inflammatory drugs or glucocorticoids increases the risk of gastrointestinal bleeding and ulceration (see section 4, Possible side effects).
Platelet aggregation inhibitors and certain antidepressants (selective serotonin reuptake inhibitors / SSRIs) may increase the risk
Some other medicines may also affect or be affected by treatment with Flexix. Therefore, always before using Flexix with other medicines, you should consult your doctor or pharmacist.
Flexistad with alcohol
Turn off alcohol during treatment with Flexixta 400 mg.
Pregnancy and breastfeeding
If you are pregnant or are breast-feeding, think you may be pregnant or plan to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.
If you become pregnant while taking Flexixad 400 mg, contact your doctor. You may take Flexixada 400 mg during the first six months of pregnancy only after consultation with your doctor.
Flexixa 400 mg should not be used in the last trimester of pregnancy due to the risk of complications for the mother and the child.
Small amounts of ibuprofen (the active substance) and its metabolites are excreted in breast milk. Since no negative effects on infants are known to occur, it is not necessary to discontinue breast-feeding for the short-term administration of the drug. However, in case of long-term intake, and / or high dosing of the medicinal product, breast-feeding should be discontinued.
Driving and using machines
Applying Flexixada 400 mg in high doses may cause central nervous system disturbances such as fatigue and dizziness, and thus affect your ability to drive and / or drive your machines.
As a result, you will not be able to respond to unexpected or sudden incidents quickly enough and carefully. You do not have to drive a car or another motor vehicle. You should not operate electrical appliances or machines. You should not work without a secure support.
3. How to take Flexistad 400 mg
Always take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, ask your doctor or pharmacist.
Dosage and route of administration, duration of therapy
These instructions apply only if your doctor has not prescribed otherwise with regard to the drug Flexixast 400 mg. Please observe these instructions for use or your doctor's instructions for effective and safe treatment with Flexixa 400 mg.
How many tablets of Flexixed 400 mg tablets should you take and how often
For the treatment of rheumatic diseases and inflammation
Ibuprofen is dosed according to body weight.
The recommended daily dose for adults and adolescents over 15 years is between 1200 and 2400 mg of ibuprofen. The maximum single dose should not exceed 800 mg Ibuprofen.
Age Single dose Total daily dose
Adolescents over 15 years old and adults 1-2 film-coated tablets (corresponding to 400 mg-800 mg ibuprofen) 3-6 film-coated tablets (corresponding to ibuprofen 1200 mg-2400 mg)
Swallow the tablets with plenty of fluids (such as a glass of water) and after a meal.
If you have a sensitive stomach, take Flexix during a meal.
Duration of treatment
In rheumatic diseases, treatment with Flexixad 400 mg may last for a longer period of time. For the duration of treatment, your doctor will decide.
Take Fluoxast 400 mg as directed by your doctor and / or follow the instructions in this leaflet. If relief of pain is inadequate, you should not increase the dose at your discretion but consult your doctor.
If you take more than the required dose of Flexixa 400 mg
Always take this medicine exactly as your doctor has told you. If you feel that the effect of the medicine is not strong enough to relieve the pain, do not increase the dose yourself! Consult your doctor.
Symptoms of overdosage may include central nervous system disorders such as headache, dizziness, dizziness and loss of consciousness (also in myoclonic spasms in children) as well as abdominal pain, nausea and vomiting. Patients may experience gastrointestinal bleeding and impaired liver and kidney function. An overdose may also lead to a fall in blood pressure, respiratory depression and bluish / reddish skin and mucous membrane (cyanosis).
There is no specific antidote.
If you are concerned about an overdose of 400 mg of Flexixad, consult your doctor immediately, depending on the degree of poisoning, decide whether to take any specific measures.
If you forget to take Flexistad 400 mg
Do not take a double dose to make up for the missed dose. Continue the treatment according to the instructions in section H "How to take Flexixa 400 mg".
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, Flexix may cause side effects, although not everybody gets them.
Listed side effects usually
How to store Flexistad 400 mg
Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Do not dispose of medicines in the sewage system or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What contains Flexistad 400 mg
The active substance is ibuprofen. 1 film-coated tablet contains 400 mg of ibuprofen.
Excipients are: magnesium stearate, corn starch, carboxymethylcellulose sodium hydroxypropylmethyl cellulose, macrogol 400, macrogol 6000.
What the pack contains FLEXISTA 400 mg
Original pack of 20, 50 and 100 film-coated tablets
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