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Flexistad 800 mg. 20 tablets

Brand: STADA
Product Code: Flexistad 800 mg. 20 tablets
Availability: In Stock
Product viewed: 116

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What is Flexistad 800 mg and what it is used for

Flexistad 800 mg is an anti-inflammatory and pain-relieving drug (a non-steroidal anti-inflammatory drug). Flexix is ​​used for the symptomatic treatment of pain and inflammation in:

Acute inflammation of the joints (acute arthritis), including gout attacks
Chronic inflammation of the joints (chronic arthritis), especially rheumatoid arthritis / chronic polyarthritis /
ankylosing spondylitis (Behterev's disease) and other inflammatory-rheumatoid diseases of the spine
inflammatory conditions in degenerative joint and vertebral diseases / osteoarthritis and spondyloarthrosis /
inflammatory rheumatic diseases of soft tissues
painful swelling and inflammation after injuries and injuries
2. What you need to know before taking Flexixa 800 mg

Do not take Flexistad 800 mg if:

are hypersensitive to the active substance or to any of the excipients of this medicine (listed in section 6);
if you have ever had difficulty in breathing (bronchospasm), asthma attacks, inflammation of the nasal mucosa or reactions after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs in the past;
if you have a history of recurrent stomach / duodenal ulcer (peptic ulcer) or bleeding (at least two different episodes of diagnosed ulcer or bleeding);
if you suffer from unclear haematopoiesis / blood circulation disorders;
if you suffer from gastrointestinal bleeding or perforation associated with previous treatment with non-steroidal anti-inflammatory drugs (NSAIDs);
if you suffer from cerebrovascular (cerebrovascular) or other active bleeding (bleeding);
in severe heart failure (myocardial ischemia);
in the last trimester of pregnancy;
in children and adolescents under 15 years of age.
Warnings and precautions
Check with your doctor or pharmacist before taking Flexstone.
The conditions listed below describe how you can take Flexxed under certain conditions with caution and caution (at longer dosing intervals or at a reduced dose and under medical supervision). Ask your doctor for advice. This also applies if you have had any of the listed conditions in the past.

Gastrointestinal diseases
The concomitant administration of Flexixa with other non-steroidal anti-inflammatory drugs (NSAIDs), including the so- inhibitors of cyclooxygenase (COX-2 inhibitors). Adverse reactions occur less frequently when the lowest effective dose is used for the shortest amount of time needed to control the symptoms.

Elderly patients
In the elderly, the incidence of side effects, especially bleeding from the gastrointestinal tract and perforation, is higher and sometimes these side effects in the elderly may be fatal. Therefore, patients in this age group should be closely monitored.

Bleeding from the gastrointestinal tract, ulcers and perforation
Bleeding from the gastrointestinal tract, ulcers and perforation, in some cases fatal, have been reported with NSAIDs. These reactions may occur at any time during treatment, with or without warning symptoms or a history of serious gastrointestinal disease.
The risk of gastrointestinal bleeding, ulceration and perforation is higher at dose escalation and in patients who have had ulcers in the past, particularly ulcers, complications, bleeding and perforation (see section 2, "Do not take Flextastic"), and in elderly patients. Such patients should start treatment with the lowest effective dose.
Patients who are prescribed low-dose acetylsalicylic acid or other medicines known to cause gastrointestinal disorders should also be given concomitant medication (such as missoprostol or proton pump inhibitors ).

If you have experienced gastrointestinal side effects in the past, especially if you are elderly, you should report any abnormal abdominal symptoms (such as bleeding), especially if they occurred at the beginning of treatment.

If you take other medicines that may increase the risk of ulcer or bleeding, such as oral corticosteroids, anticoagulants (blood clotting-lowering drugs such as warfarin), selective serotonin reuptake inhibitors (used to treat depression and other psychiatric disorders) or inhibitors of platelet aggregation (for example, acetylsalicylic acid), your doctor should regularly monitor blood clotting to avoid potential bleeding em (see section 2, "Other medicines and Fleksistad").

Treatment should be discontinued if you develop gastrointestinal bleeding or ulceration during treatment with Flexix.

NSAIDs should be used with caution in patients with gastrointestinal disorders or in doubt
Concomitant administration of Flexistad with digoxin (a medicine used to enhance the heart), phenytoin (anticonvulsant medicine) or lithium (a medicine to treat manic mental disorders) can lead to an increase in serum concentrations of these drugs. Continuous control of the levels of lithium in the blood. Control of digoxin and phenytoin levels is recommended.

Flexistad 800 mg may reduce the action of diuretics and antihypertensive medicines (detoxifying tablets and lower blood pressure medicines).

Flexistad 800 mg may reduce the effect of ACE inhibitors (used to treat heart failure and high blood pressure).
Concomitant use of these medicines may increase the risk of kidney function impairment.

Concomitant administration of Flexistad  800 mg and potassium-sparing diuretics (some diuretics) may lead to hyperkalaemia (increase in potassium in the blood).

Concomitant administration of Flexistad 800 mg and other non-steroidal anti-inflammatory drugs or glucocorticoids increases the risk of gastrointestinal bleeding and ulceration (see section 4, Possible side effects).

Platelet aggregation inhibitors and certain antidepressants (selective serotonin reuptake inhibitors / SSRIs) may increase the risk of gastrointestinal bleeding.

Experimental data indicate that ibuprofen may suppress the action of acetylsalicylic acid at low doses on platelet aggregation. These data are limited and no firm conclusions can be drawn about the regular use of ibuprofen, and such clinical effect is unlikely. Talk to your doctor before starting to take Flyoxad and acetylsalicylic acid in low doses as an anti-caking agent.

Applying Flexistad 800 mg within 24 hours before and after taking methotrexate may lead to an increase in methotrexate concentration and, therefore, to an increase in the toxic effect of methotrexate.

Concomitant use of certain non-steroidal anti-inflammatory drugs increases the risk of kidney damage by ciclosporin (a medicine used to prevent transplant rejection as well as to treat rheumatic conditions). This effect also applies to the combination of ciclosporin and ibuprofen.

Products containing probenecid or sulfinpyrazone (medicines used in gout) may delay the emission of ibuprofen. This can lead to accumulation of ibuprofen in the blood and exacerbation of its side effects.

There are single reports of interactions between Flexixa 800 mg and anticoagulants such as warfarin. Blood clotting should be controlled when taking concomitantly with ibuprofen and anticoagulants.

Clinical studies have shown interaction between non-steroidal anti-inflammatory drugs and sulphonylureas (oral antidiabetic products). Although there is no relationship between ibuprofen and sulfonylurea, it has been reported that patients taking both products at the same time should control the blood glucose concentration to avoid potential complications.

Tacrolimus: There is an increased risk of nephrotoxicity when ibuprofen and tacrolimus are co-administered.

Zidovudine: In HIV-positive patients with haemophilia, there is a greater risk of haemarthrosis and hematoma when zidovudine and ibuprofen are co-administered.

Some other medicines may also affect or be affected by treatment with Flexix. Therefore, always before using Flexix with other medicines, you should consult your doctor or pharmacist.

Flexistad with alcohol
Turn off alcohol during treatment with Flexix 800 mg.

Pregnancy and breastfeeding
If you are pregnant or breast-feeding, think you may be pregnant or plan to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.

If you become pregnant while receiving Flexixada 800 mg, contact your doctor. You may take Flexixa 800 mg during the first six months of pregnancy only after consultation with your doctor.

Flexistad 800 mg should not be used in the last trimester of pregnancy because of the risk of complications for the mother and the child.

Small amounts of ibuprofen (the active substance) and its metabolites are excreted in breast milk. Since no negative effects on infants are known to occur, it is not necessary to discontinue breast-feeding for a short period of time. However, in case of long-term intake, and / or high dosing of the medicinal product, breast-feeding should be discontinued.

Driving and using machines
Applying Flexixada 800 mg in high doses may cause central nervous system disturbances such as fatigue and dizziness, and thus affect your ability to drive and / or your ability to operate machinery.

As a result, you will not be able
Duration of treatment
In rheumatic diseases, treatment with Flexistad 800 mg may last for a longer period of time. For the duration of treatment, your doctor will decide.
Take Flexistad  800 mg as prescribed by your doctor and / or follow the instructions in this leaflet. If relief of pain is inadequate, you should not increase the dose at your discretion but consult your doctor.

If you take more than the required dose of Flexistad  800 mg
Always take this medicine exactly as your doctor has told you. If you feel that the effect of the medicine is not strong enough to relieve the pain, do not increase the dose yourself! Consult your doctor.

Symptoms of overdosage may include central nervous system disorders such as headache, vertigo, dizziness and loss of consciousness (also in myoclonic spasms in children) as well as abdominal pain, nausea and vomiting. Patients may experience gastrointestinal bleeding and impaired liver and kidney function. An overdose may also lead to a fall in blood pressure, respiratory depression and bluish / reddish skin and mucous membrane (cyanosis).
There is no specific antidote.
If you are concerned about an overdose of 800 mg of Flexixad, consult your doctor immediately, depending on the degree of poisoning, decide whether to take any specific measures.

If you forget to take  Flexistad 800 mg
Do not take a double dose to make up for the missed dose. Continue the treatment according to the instructions in section H, "How to take  Flexistad 800 mg".

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, Flexix may cause side effects, although not everybody gets them.

The listed adverse drug reactions are usually dose-dependent and may vary in individual patients.

The most commonly observed side effects are gastrointestinal tract infections. Gastric ulcers or duodenal ulcers (peptic ulcers), perforation or gastrointestinal bleeding, sometimes fatal, occur mainly in the elderly (see section 2 "Warnings and Precautions"). The following reactions have been observed following administration of ibuprofen: nausea, vomiting, constipation, flatulence, indigestion, abdominal pain, dark stools, vomiting of blood, inflammation of the mouth, ulceration (ulcerative stomatitis), worsening of colitis and Crohn's disease (see section 2 "Warnings and Precautions"). Rarely, inflammation of the stomach (gastritis) is observed. The risk of gastrointestinal bleeding depends on the dose and duration of treatment.

Medicines such as Flexistad  800 mg may be associated with a slightly increased risk of a heart attack ("myocardial infarction") or stroke.

Very common (may affect more than 1 in 10 patients)

gastrointestinal complaints such as heartburn, stomach pain, vomiting, diarrhea, constipation, and mild gastrointestinal bleeding, which may lead to anemia.
If severe upper abdominal pain or vomiting of blood, and / or bloody / tar black stools occur, stop taking Flexix 800, consult a doctor.

Common (may affect 1 in 10 patients):

central nervous system disorders - headache, dizziness, insomnia, agitation, irritability and fatigue.
gastrointestinal or duodenal ulcer with bleeding and / or perforation in isolated cases, irritation of the mouth with ulcers (ulcerative stomatitis), worsening of colitis and Crohn's disease.
If severe upper abdominal pain or vomiting of blood, and / or bloody / charcoal stools occur, stop taking Flexixa 800 mg and seek medical advice immediately.

Uncommon (may affect 1 in 100 patients):

hypersensitivity reactions with skin rashes and skin pruritus as well as asthma attacks (with possible lowering of blood pressure)
In this case, immediately seek a doctor and stop taking Flexixa 800 mg.

visual disturbances
increased fluid retention in edema tissues, especially in patients with arterial hypertension or renal failure, nephrotic syndrome (fluid retention in the body - edema and significant proteinuria in the urine), inflammatory kidney disease (interstitial nephritis) which may be accompanied by acute renal failure. Reduced urination, fluid retention in the body (edema) and general malaise may be an expression of renal impairment to the extent of renal insufficiency.
If these symptoms occur or become worse, stop taking Flexximate 800 mg and seek medical advice immediately.
If severe upper abdominal pain or vomiting of blood, and / or bloody / charcoal stools occur, stop taking Flexixa 800 mg and seek medical advice immediately.

Very rare (may affect from 1 to 10
How to store Flexistad 800 mg

Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.

Do not dispose of medicines in the sewage system or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.

6. Package Contents and Additional Information

What contains Flexistad 800 mg

The active substance is ibuprofen. 1 film-coated tablet contains 800 mg of ibuprofen.
Excipients are: magnesium stearate, corn starch, carboxymethylcellulose sodium hydroxypropylmethyl cellulose, macrogol 400, macrogol 6000.
What FLEXISTAD 800 mg contains
Original pack of 20, 50 and 100 film-coated tablets






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