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ABRICEF WHAT IS AND WHAT IT IS USED FOR?
The active ingredient contained in this product is cefotaxime - antibiotic cephalosporin. Has pronounced activity against a significant number of bacteria that cause sometimes severe infections in humans. Inhibits the formation of the cell wall of the bacteria, and thereby prevents their propagation.
Abricef be used to treat infections caused by susceptible to the action of microorganisms such as cefotaxime:
• Respiratory tract infections - acute and chronic bronchitis, certain types of pneumonia, lung abscess, etc. .;
• Infections of the genitourinary system - acute and chronic infections of the kidney tissue (pyelonephritis) and urinary tract infections, gonorrhea; infections in the pelvis;
• Infections of the abdominal organs;
• blood infection, sepsis, the inner lining of the heart (endocarditis), the cladding of the brain (meningitis);
• Infections of the bones and joints;
• Infections of the skin and soft tissues;
• Lyme disease - an infectious disease which is transmitted by the rodents and is caused by a specific bacteria;
Abricef be taken to prevent infections before and after surgery.
2 BEFORE USING ABRICEF
Do not apply Abricef:
• if you are allergic (hypersensitive) to cefotaxime or other cephalosporin antibiotics;
• if you are allergic (hypersensitive) to penicillin antibiotics;
Take special care with Abricef
The product should be administered with caution in the following cases:
- An allergy to antibiotics, other drugs, asthma
Before starting treatment with this product should tell your doctor if you have had in the past or you suspect that you are allergic to antibiotics, other medicines or suffer from asthma. During treatment with this product can not be totally excluded the possibility of occurrence of allergic reactions, which in some cases can be very serious. Therefore, before initiating treatment with the product, the doctor will check through specific skin samples if you are not allergic to the drug.
If during treatment appeared itching, rash, swelling around the eyes and lips, difficulty breathing, wheezing, feeling of warmth, immediately consult a doctor. In these cases, treatment should be discontinued immediately and appropriate therapy.
If the disease has resulted in a significant reduction in renal function is necessary to reduce the dose administered. The exact dosage will be determined by your doctor according to indicators of the state of renal function.
- Heart disease
It is necessary to know that the product contains sodium (48 mg / g), and this should be taken into account by patients who need to restrict the intake of salt in the diet (e.g.. Patients with high blood pressure, heart failure - heart disease occurring with tiredness, shortness of breath, swelling of the ankles).
Like other antibiotics, prolonged treatment with the product, the possibility of "overgrowth" resistant to the action of microorganisms cefotaxime, incl. Fungi. In these cases it is necessary to start a specific antibacterial treatment that your doctor will decide according to your condition.
During treatment or after its completion possible development etc. Pseudomembranous colitis (the case of infectious intestinal inflammation manifested severe, persistent diarrhea). In case you receive such complaints, tell your doctor immediately, who will appoint the appropriate laboratory and microbiological tests and take necessary treatment.
With prolonged treatment (over 10 days) should be performed periodically blood test is possible because the number of red and white blood cells decrease. In some cases this may require discontinuation of treatment.
The product should not be used in solutions containing lidocaine in the following cases:
- For intravenous administration;
- In children aged <30 months;
- In patients with allergy to lidocaine;
- Patients with certain heart conditions (eg. Impaired ability of the heart to conduct impulses, etc. heart block, severe heart failure).
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
The product should be used with caution in patients concomitantly treated with aminoglycoside antibiotics (eg. Gentamicin, tobramycin, amikacin) or diuretics (drugs that enhance the flow of urine) such as furosemide. These drug combinations can result in a risk of impairment of renal function.
This product does not have to be administered concomitantly with antibiotics tetracycline and chloramphenicol, thereby reducing mutual its effect.
Probenecid reduces emission of cefotaxime in the kidneys and lead to higher concentrations in the blood.
The effect of the contraceptive pill may be reduced during treatment with cefotaxime. It is therefore recommended their effect be secured through the use of additional tools and methods of contraception.
It is possible to monitor changes in the results of some laboratory tests (eg. False positive test results of Coombs, some test for sugar in the urine). Therefore, if you have to be carried out laboratory tests, tell your doctor that you are being treated with cefotaxime.
Taking Abricef with food and drink
There are certain restrictions.
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine. Pregnancy: Animal studies conducted have shown no adverse effects on the fetus, but to avoid any possible risk to the baby, the product should not be used during pregnancy, especially in the first three months. This is only possible when the physician has determined that the expected benefit to the mother is greater than any possible risk to the fetus. Lactation active substance is excreted in breast milk in small quantities. Your doctor will assess the need for cessation of breastfeeding during the treatment with the product.
Driving and using machines
There is no evidence that cefotaxime may directly affect the ability to drive and use machines but the treatment it may appear dizziness, which could impair the ability to drive and use machines
3 HOW TO USE ABRICEF?
Abricef will be administered by a doctor or nurse.
The product can be administered intramuscularly or into a vein. Dose, route and frequency of administration are determined according to the severity of infection, susceptibility of the causative organism and the patient's condition. adults
The recommended dose for mild and moderate infections is 1 g twice daily at 12 hour intervals. In severe infections, the dosage can be increased to 12 g per day, equally divided into 3-4 doses. children
The recommended daily dose is 100-150 mg / kg, divided into 2-4 doses evenly. In severe infections, it may be increased to 200 mg / kg.
The recommended daily dose is 50 mg / kg, divided into 2-4 doses evenly and in severe infections usually need a dose of 150 to 200 mg / kg.
A single dose of 1 g, administered intramuscularly or intravenously.
Patients with renal impairment
Your doctor will decide depending on the condition of the kidneys exact dose. Usually begins with the usual dose of 1 g per 12 hours, which is then reduced to 0.5 g every 12 hours.
Patients with hepatic impairment
Not require dose adjustment.
Preparation of the solution
The contents of the vials Abricef lg is dissolved by shaking, respectively, with 4 ml of sterile water for injection or sterile solution of 1% lidocaine hydrochloride. Injected deep intramuscularly. intravenous
For direct intravenous injection - the contents of the vials Abricef lg was dissolved by stirring with 10ml of sterile water for injections. Injected for 3-5 minutes. For intravenous infusion, - the contents of the vials Abricef 1 g is dissolved by shaking with at least 10 ml of sterile water for injection and then diluted in 40-100 ml of one of the following infusions: 0.9% sodium chloride, 5% or 10 % glucose, 5% glucose and 0.9% sodium chloride, sodium lactate, or sterile water for injection. Intravenous infusion is carried out for 20-60 minutes.
The reconstituted product for injection is a light yellow or yellow to light amber color, depending on the concentration, the solvent used and the storage conditions. Recommended solutions to inlay immediately after preparation. If this is impossible, the reconstituted solution can be stored for up to 24 hours at 2 ° to 8 ° C (in a refrigerator).
Prepared with lidocaine solutions Abricef lg for intramuscular administration not administered intravenously!
If you are given more than the required dose Abricef
It is unlikely that the health care professional to give you a higher dose of the drug. If you have any doubt, talk to your doctor.
If you missed a dose administered Abricef
If omitted administration of one dose is to be administered as soon as possible, if the time until the next dose is sufficiently long. Otherwise, the next dose at the usual time ..
If you stop taking Abricef
Do not stop the use of the product if you feel better, unless your doctor tells you that.
If you have any other questions about the use of this product, ask your doctor or pharmacist.
4 POSSIBLE SIDE EFFECTS
As with all medications, Abricef can cause side effects, although not everyone gets them. The following is the frequency with which they are reported side effects: Common - affects more than one in every 100 patients and less than one in ten taking the product.
Uncommon - occurring in at least one out of 1000 and less than one in 100, taking the product
Rare - occurring in one in 10,000 and less than one in 1000, taking the product
Very rare - occurs in less than 1 patient in ten thousand who received the product. Adverse reactions associated with the use of cefotaxime usually mild, transient and infrequent. Possible side effects are the following:
Infections and infestations
Rare - overgrowth of non-susceptible organisms, including. fungi, pseudomembranous colitis (infectious, inflammatory bowel disease, manifested by severe, persistent diarrhea). Blood and lymphatic system
Rare - reductions in certain or all of the white blood cells, decrease the number of blood platelets (thrombocytes), anemia. Nervous System Disorders
Uncommon - headache, dizziness
Rare - in high doses, particularly in patients with renal failure are possible disturbance of consciousness, involuntary movements, seizures. cardiac disorders
Very rare - heart rhythm disturbances, usually in intravenous
Common - diarrhea, nausea, vomiting, abdominal pain
Rare - temporary, reversible elevation of liver enzymes, bilirubin, alkaline phosphatase, hepatitis, jaundice Skin and subcutaneous tissue disorders Common - rash, itching, hives (urticaria)
Very rare - severe allergic reactions - swelling around the eyes, lips, tongue, which can be life-threatening (ie angioedema), difficult breathing wheezing (bronchospasm), allergic shock, serious skin blistering. Renal and urinary disorders
Rare - disturbances in kidney function, especially in high-dose therapy or concomitant therapy with aminoglycoside antibiotics Very rare - renal tissue, etc. nephritis General disorders and administration site conditions
Common - pain at the injection site inflammation of the vein in which to inject the drug.
If any of the side effects gets serious, or get any side effects not listed in this leaflet, please contact your doctor or pharmacist.
5 HOW TO STORE ABRICEF?
At temperatures below 25 ° C.
After reconstitution, store at 2 to 8 ° C (refrigerated) for up to 24 hours! Keep out of reach of children. Store in original container protected from light. When storing the color of the reconstituted solution may be more intense. Abricef not use after the expiry date stated on the carton. The period of, to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
6 FURTHER INFORMATION
Active substance in a bottle: Cefotaxime sodium salt (Cefotaxime sodium) 1.048 g, Eq. lg of Cefotaxime (Cefotaxime)
Excipients: The product does not contain excipients
Abricef looks like and contents of the pack?
Description - white or pale yellow powder.
Abricef lg powder for injection in colorless glass vials containing 30 ml of 1 piece per carton.
Abricef lg powder for injection in colorless glass vials containing 30 ml of 10 pieces per carton.
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