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What is Tiapride G.L. and what it is used for
Tiaprid G.L. belongs to a group of medicines called "antipsychotic" that affect various processes in the central nervous system.
Tiaprid G.L. is used to treat patients with various types of motor disorders and behavioral abnormalities due to various causes (eg, certain diseases, advanced age or chronic alcohol consumption).
2. What you need to know before you take Tiaprid G.L.
Do not take Tiaprid G.L.
if you are allergic to thiapride hydrochloride or any of the other ingredients of this medicine (listed in section 6);
if you have a hormone-sensitive tumor, for example the pituitary gland (pituitary) or breast cancer;
if you have a tumor of the adrenal medulla (called "pheochromocytoma");
if you are taking levodopa or other medicines to treat Parkinson's disease.
Warnings and precautions
Talk to your doctor or pharmacist before taking Tiaprid G.L.
When you are taking Tiaprid G.L. special precautions are required:
in patients who have had epilepsy: like other antipsychotic agents, Tiapride G.L. is likely to increase the likelihood of an epileptic seizure. Therefore, these patients should be closely monitored by a doctor;
in patients with Parkinson's disease: the physician will prescribe Tiapird G.L. only in exceptional cases;
in patients with severe cardiovascular disease (heart and circulatory disorders including heart rhythm disturbances): cardiovascular side effects may occur, for example, low blood pressure;
in elderly patients: like other antipsychotic drugs, Tiaprid G.L. can lead to marked fatigue and low blood pressure;
in elderly patients with dementia: similar to other central nervous system drugs, Tiapird G.L. may increase the likelihood of a stroke. If you have had a stroke in the past, tell your doctor. He will monitor you strictly;
in patients with kidney disease: the doctor will reduce the dose as much as necessary (see section 3 How to take Tiaprid G.L.);
if you have complaints at the same time as fever, muscle stiffness or consciousness or circulatory disorders: these may be neuroleptic malignant syndromes that can lead to death in serious cases. If you have a fever of unknown origin, contact your doctor immediately and stop taking Tiaprid G.L .;
if you have or have had a risk of blood clots: your doctor will prescribe Tiaprid G.L. very cautious, as medicines like this are associated with blood clotting.
Tell your doctor before starting treatment if:
have slow heartbeat;
you have a disturbed electrolyte balance, especially a low potassium level;
if you have a congenital heart rhythm disorder (so-called QT prolongation);
if you are taking medicines that can cause the symptoms and symptoms described above.
In these cases, the doctor will closely monitor your heart function (see also "Other medicines and Tiaprid G.L.")
Children and adolescents
The use of Thiapitz G.L. in children under 12 years of age has not been studied sufficiently. Therefore, the physician will carefully assess the potential treatment with Tiaprid G.L.
Other Drugs and Tiaprid G.L.
Tell your doctor if you are taking, have recently taken or might take any other medicines.
Tiaprid G.L. should not be combined with Levodopa (used for Parkinson's disease).
Combinations of Tiapride G.L. with the following medicines:
Medicinal products that may cause dangerous heart rhythm disorders (torsades dig pointes), eg,
medicines for certain cardiac disorders (class 1a and class III antiarrhythmics, eg quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutylide and bepridil);
some drugs with central nervous system depressant and sedating effects (eg, sulpride, pipotiazine, serpindol, veralipid, chlorpromazine, lemomepromazine, triflurazine, cyamemazine, sulpiride, pimozide, haloperidol, droperidol, fluphenazine, pipamperon, flupentixol, zuclopenthixol); some antiparasitic drugs (eg halofantrine, lumfrantin, pentamidine);
medicinal products against bacterial infections: erythromycin spiramycin (injection), moxifloxacin, spafloxacin;
anti-emetic medicinal products: cisapride;
medicinal products for gastrointestinal diseases: difenmanyl;
anti-allergy medicaments: mizolastine;
medicinal products for impaired blood circulation in the brain: vincamine (injectable);
medicinal product for psychiatric disorders: sulpodride, lithium, thioridazine.
Alcohol-containing medicinal products: this combination may result in extreme fatigue.
Medicinal products used to treat Parkinson's disease (except for levodopa that should not be combined): amantadine, apomorphine
Medicines that can slow heart rate, as there is a risk of severe heart rhythm abnormalities, eg:
antiarrhythmic drugs (class 1a antiarrhythmics, class II antiarrhythmics);
medicines used to treat high blood pressure or heart failure (beta-blockers such as bisoprolol, carvedilol, metoprolol, nebivolol, calcium antagonists (diltiazem, verapamil), clonidine or cardiac glycosides;
medicines used to treat glaucoma (pilocarpine);
medicines used to treat some muscular disorders (cholinesterase inhibitors).
Medicines that can reduce potassium in the body as there is a risk of severe heart rhythm abnormalities, eg:
some diuretics (so-called "water tablets");
medicines used to treat fungal infections (amphotericin B injection);
anti-inflammatory drugs (glucocorticosteroids);
medicines for the evaluation of renal function (tetracosactide and coinplant).
Blood pressure lowering drugs, as there is a risk of excessive decrease
Medicines with depressant effect on the central nervous system as concomitant use can lead to severe suppression:
e.g. analgesics, antitussive agents, morphine derivatives for substitution therapy in addiction; sedatives, antidepressants, most H1 antihistamines against allergic diseases; high blood pressure medicines, baclofen (for relaxing muscles), thalidomide (sedative), pizotaphene (for migraine and loss of appetite).
Nitrate derivatives and related compounds (for heart and vessel diseases)
Tiaprid G.L. with alcohol
Avoid concomitant administration of Tiaprid G.L. with drinks containing alcohol. This can lead to marked fatigue.
Pregnancy and breastfeeding
If you are pregnant or breast-feeding, think you may be pregnant or plan to become pregnant, talk to your doctor before taking this medicine.
During pregnancy, your doctor will prescribe Tiaprid G.L. only if it is absolutely necessary. He will recommend treatment for the shortest possible period of time. In new-born babies or their mothers who have used Tiaprid G.L. during the last trimester (the last three months of their pregnancy) the following symptoms may occur: shaking, muscle stiffness and / or weakness, drowsiness, agitation, breathing problems and difficulty in eating. If your baby develops any of these symptoms, you may need to contact your doctor.
It is unknown whether Tiaprid G.L. is distributed in milk. Therefore, during breast-feeding, use of Tiaprid G.L.
Driving and using machines
This medicine can disrupt your ability to drive and react.
It is possible to use Tiaprid G.L. to lead to dizziness, drowsiness and fatigue. You should not take part in traffic, operate machinery or do other risky activities if you are not sure that Tiaprid G.L. does not violate your ability to deal with these activities.
3. How to take Tiaprid G.L.
Always take this medicine exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.
The recommended dose is:
Adults and adolescents (12 to 18 years old)
In motor disorders due to the elderly:
200-400 mg Tiapride G.L. daily (2 to 4 tablets)
In motor disorders due to chronic alcoholism:
300-400 mg Tiapride G.L. daily (3 to 4 tablets)
In motor disorders due to other causes:
150-1200 mg Tiapride G.L. daily (VA to 12 tablets). Your doctor may tell you to divide the total daily dose into 3 to 5 doses.
Impaired renal function
Your doctor will prescribe a lower dose for you.
Impaired liver function
No dose change is required.
Tablets Tiapride G.L. you need to eat whole foods. Swallow the tablets with a sufficient amount of liquid (eg with a glass of water).
The tablet can be divided into equal doses (halves and quarters).
Duration of application
The duration of treatment will be decided by your doctor.
If you take more Tiaprid GL than you should
Limited experience with overdose with Tiaprid G.L. If you take more than the usual dose, you may experience various symptoms such as drowsiness and fatigue, low blood pressure and coma. Tell your doctor straight away or visit the nearest hospital.
Necessary measures to be taken:
As no specific antidote is known, your doctor will treat you as your symptoms work. A doctor's advice on overdose treatment can be found at the end of this leaflet.
If you forget to take Tiaprid G.L.
Do not take a double dose to make up for the missed dose. Follow the prescription as usual.
If you stop taking Tiaprid G.L.
Successful treatment requires regular intake during the prescription period and at a dose defined
Blood clots in the veins, especially in the legs (symptoms include swelling, pain and redness of the leg), which can move through the blood vessels to the lungs and cause chest pain and difficulty in breathing. Blood clots in the lungs can even lead to death
Lowering blood pressure when getting up, resulting in dizziness, tinnitus, malaise. If you notice any of these symptoms, consult a doctor immediately. Heart rhythm disturbances leading to ventricular fibrillation or cardiac arrest Elderly patients with dementia have reported a slight increase in the number of deaths in antipsychotic patients compared with with those who are not being treated with these medicines. The reason for this is unknown
Aspiration pneumonia (due to pulp feeding or vomiting)
Constipation, intestinal obstruction
Elevated liver enzymes
Increase in blood creatine phosphokinase levels, muscle weakness and / or muscle pain
How to Store Tiapride G.L.
Keep out of the reach and sight of children.
This medicinal product does not require any special storage conditions.
Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Do not dispose of medicines in the sewage system or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What Tiaprid G.L.
The active substance is thiapride hydrochloride. 1 tablet contains 111.1 mg of tadapride hydrochloride corresponding to 100 mg of tiapride.
The other ingredients are: mannitol, microcrystalline cellulose, magnesium stearate, povidone, colloidal anhydrous silica.
What Tiaprid G.L. and what the package contains
Tablets Tiapride G.L. are white, round tablets with bevelled edges and two dividing lines on both sides.
Tiaprid G.L. tablets are packed in PVC / aluminum blister packs of 20, 30, 50, 60, 90, 100 and 500 (10x50 carton) tablets.
Not all pack sizes may be marketed.
Advice for the doctor in cases of overdose:
The overdose experience of Tiaprid G.L. is limited. Drowsiness, sedation, coma and extrapyramidal symptoms may occur
In cases of severe overdose, the possible intake of various drugs should be considered.
Hemodialysis should not be used to remove the active substance because Tiapird G.L. is dialyzed to a moderate extent.
There is no specific antidote for Tiapride G.L. Therefore, treatment should be symptomatic. It is important to have symptomatic intensive care with heart function monitoring (risk of QT prolongation and subsequent ventricular arrhythmias) and close monitoring of vital functions until recovery.
In cases of acute extrapyramidal symptoms, anticholinergic drugs should be used.
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