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WHAT HUMALOG MIX 25 PEN AND WHAT IT IS USED
Humalog Mix 25 Pen is used to treat diabetes. It is a premixed suspension. The active substance is insulin lispro. 25% insulin lispro Humalog Mix 25 are dissolved in water and it works more quickly than normal human insulin because the insulin molecule has been changed slightly. 75% of insulin lispro Humalog Mix 25 are in the form of a suspension together with protamine sulphate, so that its action is prolonged.
You get diabetes if your pancreas does not produce enough insulin to control the level of glucose in the blood. Humalog Mix 25 substitute for your own insulin and is used to control glucose in the long term. Humalog Mix 25 run faster and for longer than soluble insulin. You should normally use Humalog Mix 25 to 15 minutes before eating.
Your doctor may advise you to use Humalog Mix 25 Pen, as well as longer-acting insulin. Each kind of insulin comes with another patient information leaflet that explains its properties. Do not change your insulin unless your doctor tells you that. Be very careful if you change your insulin.
2. BEFORE YOU USE HUMALOG MIX 25 PEN
Do not use Humalog Mix 25 Pen
if you think hypoglycaemia (low blood sugar). Further in this leaflet explains what to do if moderate hypoglycemia;
if you are allergic (hypersensitive) to insulin lispro or any of the other ingredients of Humalog Mix 25 Pen.
Take special care with Humalog Mix 25 Pen
If the sugar levels in the blood are well controlled by your current insulin therapy, you may not feel the warning symptoms when blood sugar levels fall too low. Warning signs are listed later in this leaflet. You must think carefully about when to eat, how often and intensively you exercise. You should carefully monitor the level of your blood sugar through frequent blood glucose testing;
A few people who have had hypoglycaemia after switching from animal insulin to human insulin have reported that the early warning symptoms were less obvious or different. If you often have hypoglycaemia or have difficulty recognizing it, please discuss this with your doctor;
If you answer "YES" to any of the following questions, tell your doctor, pharmacist or diabetes nurse:
Have you recently become ill ?;
Do you have problems with your kidneys or liver ?;
Are you being more physical exercise than usual ?;
The amount of insulin you need may change if you drink alcohol;
You should also tell your doctor, pharmacist or diabetes nurse if you are planning to travel abroad. The time difference between countries may mean that you have to have your injections and meals at different times than you are at home;
Some patients with long-standing type 2 diabetes mellitus and heart disease or previous stroke who were treated with pioglitazone and insulin, have developed heart failure. Tell your doctor as quickly as possible if you experience signs of heart failure such as unusual shortness of breath or rapid increase in weight or localized swelling (edema).
Using other medicines
Your insulin needs may change if you take birth control pills, steroids, hormone replacement therapy thyroid, oral products to reduce blood sugar, aspirin, antibiotics, containing "sulfa" group, octreotide, "beta 2 stimulants" (for example ritodrine, salbutamol or terbutaline), beta-blockers, or some antidepressants (monoamine oxidase inhibitors or selective serotonin reuptake inhibitors), danazol, some angiotensin converting (ACE) inhibitors (e.g., captopril, enalapril), and blockers of angiotensin II receptors .
Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Pregnancy and lactation
Are you pregnant or thinking about becoming pregnant or breastfeeding? The amount of insulin you need usually falls during the first three months of pregnancy and increases for the remaining six months. If you are breastfeeding you may need to change your insulin intake or diet. Ask your doctor.
Driving and using machines
Ability to concentrate and react may be reduced if you have hypoglycaemia. Please note all this in all situations where you might put yourself and others at risk (eg. Driving or operating machinery). You should contact your doctor about the advisability of driving if you have:
frequent episodes of hypoglycemia;
reduced or absent warning signs of hypoglycaemia.
3. HOW TO USE HUMALOG MIX 25 PEN
Always check the pack and the label of the pre-filled pen for the name and type of the insulin when you get it from your pharmacy. Make sure you get the Humalog Mix 25, which tells you your doctor.
Always use Humalog Mix 25 just as you have been told your doctor. If you're not sure, ask your doctor.
You should normally inject Humalog Mix 25 15 minutes before eating. If necessary can inject soon after a meal. But your doctor will tell you exactly how much to use, when to use it and how often. These instructions are only for you. Follow them exactly and visit your diabetes clinic regularly;
If you change the type of insulin you use (for example from a human or animal insulin to Humalog-ov product), you may have to take more or less than before. This might just be for the first injection or it may be a gradual change over several weeks or months;
Inject Humalog Mix 25 subcutaneously. You should not use it otherwise. Under no circumstances Humalog Mix 25 should not be administered intravenously.
Preparing Humalog Mix 25 Pen
Before use, the pen should be rotated ten times between the palms of your hands and turn 180 ° ten times to insulin to mix so that it appears uniformly cloudy or milky. If not, repeat the above procedure until contents are mixed. The cartridges contain a small glass ball to aid in mixing. Do not shake vigorously as this may result in the formation of foam, which will interfere with measurement of dose. The cartridges should be examined frequently and should not be used if there are lumps or the bottom or wall of solid white particles, giving it a frosted. Check each time you inject yourself.
Preparation of the Pen (pen) for use
First wash your hands;
Read the instructions on how to use pre-filled insulin pens. Please carefully follow the instructions. There are some reminders;
Use a clean needle. (Needles are not included);
Prepare your pen before each use. This checks that insulin comes out and clears the air bubbles from your pen. There may be still be some small air bubbles in the Pen (pen) - these are harmless. If air bubbles are too large, it can affect your insulin dose.
Injecting Humalog Mix 25
Before you make an injection, clean your skin as you have been instructed. Inject under the skin, as you were told. Do not inject directly into a vein. After your injection, leave the needle in the skin for five seconds to make sure that you take the entire dose. Do not rub the area you have just injection. Make sure you inject at least half an inch (1cm) from the last injection and that you change injection sites as you were trained.
At the moment the injection, remove the needle from the pen using the outer needle cap. This will keep the insulin sterile and prevent leaking. It also stops air entering the pen and your needle clogging. Do not share your needles to others. Do not share your pen to others. Replace the cap on your Pen (pen).
Every time you use a Pen (pen) you must use a new needle. Before every injection, clear any air bubbles. You can see how much insulin is left by holding Pen (pen) with the needle pointing up. The scale on the cartridge shows about how many units remain;
Not mixed with any other insulin in your disposable pen. After Pen (pen) is empty, do not use it again. Please dispose of it carefully - your pharmacist or diabetes nurse will tell you how to do this.
If you use more than the amount of Humalog Mix 25
If you use more Humalog Mix 25 than you need, you may experience low blood sugar. Check your blood sugar. If your blood sugar is low, eat glucose tablets, sugar or drink a sugary drink. Then eat fruit, biscuits, or a sandwich, as your doctor has advised you and rest. In most cases, this will help you over mild hypoglycaemia or a minor insulin overdose. If you feel worse and your breathing is shallow and your skin gets pale, immediately contact your doctor. Too severe hypoglycemia can be treated with glucagon injection. Eat glucose or sugar after the glucagon injection. If there is no response to glucagon you will have to go to hospital. Ask your doctor to tell you about glucagon.
If you forget to use Humalog Mix 25
If you take less Humalog Mix 25 than you need, it may experience high blood sugar. Check your blood sugar.
If hypoglycaemia (low blood sugar) or hyperglycemia (high blood sugar) is not treated they can be very serious and cause headaches, nausea, vomiting, dehydration, unconsciousness, coma or even death (see A and B in section 4 "Possible side effects").
Always keep spare syringes and vials spare Humalog Mix 25 or a spare pen and cartridges, in case you lose your Pen (pen), or damaged;
Always carry something to show you are diabetic;
Always carry sugar with you.
If you stop using Humalog Mix 25
If you take less Humalog Mix 25 than you need, it may experience high blood sugar. Do not change your insulin for you, unless your doctor tells you.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Humalog Mix 25 can cause side effects, although not everybody gets them.
Local allergy is common (> 1/100, <1/10): Some people get redness, swelling or itching around the site of injection of insulin. Usually it clears up in a few days to a few weeks. If this happens to you, tell your doctor.
Systemic allergy is rare (> 1/10 000 to <000 1/1). The symptoms are the following:
rash over the whole body;
low blood pressure;
If you think you have this sort of insulin allergy with Humalog Mix 25, tell your doctor.
Lipodystrophy (thickening or pitting of the skin) is uncommon (> 1/1 000 to <1/100). If you notice your skin thickening or pitting at the injection site, tell your doctor.
If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please inform your doctor or pharmacist.
Common problems of diabetes
Hypoglycaemia (low blood sugar) means that there is not enough sugar in the blood. It can be caused if:
Take too much Humalog Mix 25 or other insulin;
miss or delay meals or change your diet;
you exercise or work too hard just before or after a meal;
you have an infection or illness (especially diarrhea or vomiting);
there are changes in your need for insulin;
You have a problem with your kidneys or liver which gets worse.
Alcohol and some medicines can affect your levels of blood sugar.
The first symptoms of low blood sugar usually come on quickly and include the following:
nervousness or shakiness;
While you are not confident about recognizing your warning symptoms, avoid situations, eg driving a car, in which you or others would be put at risk by hypoglycaemia.
B. Hyperglycaemia and diabetic ketoacidosis
Hyperglycemia (too much sugar in the blood) means that your body does not have enough insulin. Hyperglycemia may be caused by the fact that:
not take Humalog, intended for you or other insulin;
taking less insulin than you have been told by your doctor;
eating a lot more than your diet allows;
fever, infection or emotional stress.
Hyperglycemia can lead to diabetic ketoacidosis. The first symptoms come on slowly over many hours or days. The symptoms include the following:
lack of appetite;
breath smell of fruits;
feeling sick or vomiting.
Severe symptoms are heavy breathing and a rapid pulse. Seek medical help immediately.
If you're sick / on, especially if you feel sick or are sick / a, the amount of insulin you need may change. Even when you are not eating normally, you still need insulin. Test your urine or blood, follow your 'sick rules' and tell your doctor.
5. HOW TO STORE HUMALOG MIX 25 PEN
Before use, store Humalog Mix 25 Pen, designed for you in a refrigerator (2 ° C - 8 ° C). Do not freeze.
Keep your Humalog Mix 25 Pen in use at room temperature (15-30 ° C) and discard after 28 days. Do not put it near sources of heat and light. Do not store the pen you are using in the fridge. The pre-filled pen should not be stored with the needle attached.
Keep out of reach of children.
Do not use Humalog Mix 25 Pen after the expiry date stated on the label and carton. The expiry date refers to the last day of that month.
Do not use Humalog Mix 25 Pen, if there is a "rags" or solid white particles on the surface or if the wall of the cartridge looks frosty. Check this each time you inject yourself.
Medicines should not be disposed of in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
6. FURTHER INFORMATION
What Humalog Mix 25 100 U / ml Pen, suspension for injection
The active substance is insulin lispro. Insulin lispro is made in the laboratory by a 'recombinant DNA technology' process. This is a modified form of human insulin and so is different from other human and animal insulins. Insulin lispro is closely related to human insulin which is a natural hormone made by the pancreas.
The other ingredients are protamine sulphate, m-cresol, phenol, glycerol, dibasic sodium phosphate 7N2O, zinc oxide and water for injection. Sodium hydroxide or hydrochloric acid may have been used to adjust the acidity.
Looks like Humalog Mix 25 100 U / ml Pen, suspension for injection and contents of the pack
Humalog Mix 25 100 U / ml Pen, suspension for injection is a white, sterile suspension and contains 100 units of insulin lispro in each milliliter (100 U / ml) suspension for injection. 25% insulin lispro Humalog Mix 25 is dissolved in water. 75% of insulin lispro Humalog Mix 25 is in the form of a suspension together with protamine sulfate. Each Humalog Mix 25 Pen contains 300 units (3 milliliters). Humalog Mix 25 Pen comes in a pack of 5 or a multipack of 2 x 5 pre-filled pens.
Not all pack sizes may be marketed.
Humalog Mix 25 in your pre-filled pen is the same Humalog Mix 25, which comes in separate Humalog Mix 25 cartridges. Pen (pen) simply has a built in cartridge. When Pen (pen) over, it can not be used again.
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