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What is Gynipral ampoules 10 μg / 2 ml and what is it used?
Gynipral prevent the onset of premature labor or threatened abortion through inhibition of contractions of the uterus. In most cases it is possible to prolong the pregnancy until the expected date of birth.
2. Before you use Gynipral ampoules 10 μg / 2 ml of
Do not use Gynipral ampoules 10 μg / ml in 2:
• patients hypersensitive (allergic) to hexoprenaline sulfate or any of the other ingredients of Ginipral ampoules 10 ug / 2 ml;
- Increased production of hormones by the thyroid gland
- Heart disease, in particular tachyarrhythmias
- Inflammation of the myocardium
- Defects of the mitral valve and aortic stenosis idiopathic subklapna
- Advanced liver or kidney disease
- Expressed uterine bleeding (premature detachment of the placenta)
- Uterine infections
Special considerations for treatment Gynipral ampoules 10 μg / 2 ml:
It is recommended that regular monitoring of pulse and blood pressure in the mother, and the heartbeat of the fetus during the administration of Ginipral. Before and during treatment should be conducted regular ECG monitoring. Patients with individual hypersensitivity to sympathomimetic agents (drugs affecting the autonomic nervous system) may adopt Gynipral only in lower doses, individually identified and under close medical supervision.
Patients with a strong rapid pulse (more than 130 / min) and significant decreases in blood pressure, the dose should be reduced and the occurrence of shortness of breath, angina, feeling of tightness in the chest or signs of heart failure, treatment with Gynipral immediately should be discontinued.
In pregnant women, people with diabetes are advised controlling carbohydrate metabolism as Gynipral can cause varying degrees of elevation of blood sugar, especially in early treatment.
If birth is accomplished in a short period of time after application of Ginipral, the newborn should be investigated on symptoms of hypoglycemia, both because of the likelihood of crossing the placenta acid metabolites (lactate, ketone acids) and possibly due to increased acidity.
During the infusion therapy with Gynipral, in isolated cases of preceding or accompanying corticosteroid therapy was observed edema of the lung. It is therefore necessary to carry out kpinichno constant monitoring of patients undergoing infusion therapy. This is required especially for patients receiving corticosteroids or existing kidney disease and ERN gestosis (increased risk of fluid retention). Due to the potential risk of pulmonary edema infusion volume should be as small as possible and to use solutions without electrolytes.
Salt intake should be limited.
In hypokalaemia prior tocolytic therapy is necessary oral potassium in potassium deficiency because the effect of sympathomimetics on the myocardium increases.
When co-administered with a central anesthetics (Halothane for example) the heart may become more sensitive to sympathomimetics, and therefore may occur cardiac arrhythmia. Therefore Ginipral therapy should be discontinued at the planned anesthesia with halothane.
With prolonged tocolytic therapy should be monitored status of the fetus and placenta using usual procedures and research.
Clinical manifestations of premature detachment of the placenta may be weakened as a result of ongoing tocolytic therapy.
After occurred rupture of membranes, and if the cervix is expanded to 2-3 cm, the chances of successfully conducting tocolytic treatment are small.
Tocolytic therapy may aggravate the symptoms of an existing dystrophic myotonia. In these cases it is advisable the use of diphenylhydantoin (phenytoin).
Not applicable because not be used during breastfeeding.
Driving and using machines
Gynipral ampoules 10 μg / 2 ml of not affect your ability to drive and use machines.
Important information about ingredients of Ginipral ampoules 10 μg / 2 ml:
Due to the content of sulphite Ginipral ampoules 10 μg / 2 ml should not be administered to patients suffering from bronchial asthma, allergic to sulfite.
If you are taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including non-prescribed by a doctor. Ginipral ampoules 10 μg / 2 ml may interact with other medicines.
Some drugs against high blood pressure (ie. Pomegranate. Beta blockers) reduce or eliminate the effects of Ginipral ampoules 10 μg / 2 ml. The efficacy of drugs against diabetes is reduced.
Some medications improve circulation and increase the power antihistamine of adverse drug reactions (chest tightness and rapid pulse) of Ginipral.
Coffee and tea can also increase the strength of the side effects of Ginipral.
Ginipral It must not be used concomitantly with ergot alkaloids, calcium, vitamin D containing medications or dehidrotahisterol.
3. How to use Gynipral ampoules 10 μg / 2 ml?
Ginipral ampoules 10 ug / 2 ml should be used exactly as prescribed.
Route of administration: Intravenous injection or infusion.
The contents of the ampoule should be administered slowly (over a period of 5 to 10 minutes) with a perfusion pump, and when this is not possible after reconstitution with 10 ml isotonic sodium chloride solution.
1. Acute tocolysis
10 μg (1 ampoule of 2 ml). Followed by continuous infusion therapy.
2. Massive tocolysis
Starting with 10 μg (1 ampoule 2 ml) as a bolus followed by infusion with 0,3 μg / min Ginipral.
It is possible to start with infusion 0,3 μg / min Ginipral without initial bolus administration.
3. Continuous tocolysis
0,075 μg / min as a continuous drip.
If there was no birthing activity within 48 hours tocolysis can continue Giniprap tablets 0,5 mg.
Note: These doses are for guidance only. When tocolysis is necessary to refine the individual needs of each patient.
If you feel that the effect of Gynipral ampoules 10 μg / 2 ml was too strong or too weak, talk to your doctor or pharmacist.
If you have taken a larger amount than prescribed Ginipral ampoules 10 μg / 2 ml:
Symptoms can be found in regular monitoring of heart rate, increase the heart rate of the mother, tremor, twitching muscles, headache and sweating.
These symptoms can be reduced with dose reduction.
In severe cases of overdose can be administered beta adrenolytic agents because they selectively inhibit the effects of Ginipral.
Effects when treatment with Ginipral ampoules 10 μg / 2 ml:
Birth can start prematurely.
4. Possible side effects
Like all medicines, Gynipral ampoules 10 μg / 2 ml may cause side effects.
During treatment with Ginipral may occur headache, fatigue, fine tremor of the fingers, sweating, tremors and dizziness. It can also be observed lowering of blood pressure, in particular lower limit.
Reported isolated cases of irregular heartbeat, difficulty breathing, tightness in the chest. These symptoms disappear rapidly after cessation of treatment.
Blood sugar levels can be increased, especially in patients with diabetes mellitus.
Urine output decreases, especially in the initial phase of treatment. Therefore, in patients with a tendency for fluid retention in the tissues (edema formation) this process may consider increased.
Intestinal motility may be delayed during treatment. It is therefore necessary to be cared for regular bowel movements.
If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
5.Sahranenie of Gynipral ampoules 10 μg / 2 ml of
Keep at temperatures below 25 ° C, in a place protected from light.
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