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What is Prestarium CO Start and what it is used for
Prestarium Co Start is a combination of two active ingredients - perindopril and amlodipine. Both ingredients help to control your high blood pressure.
Perindopril is an ACE (angiotensin-converting enzyme) inhibitor. Amlodipine is a calcium antagonist (belongs to a class of medicines called dihydropyridines). They act together by expanding and relaxing the blood vessels to make the blood flow through them more easily and to make your heart easier to maintain good blood flow.
Prestarium Start is used to treat high blood pressure (hypertension) in adults.
2. What you need to know before you take Prestarium Startup
Do not take Prestarium Startup
if you are allergic (hypersensitive) to perindopril or any of the other ACE inhibitors or to amlodipine or other calcium antagonists or any of the other ingredients of this medicine (listed in section 6); if you have severe kidney problems;
if you have experienced symptoms such as swirling breathing, swelling of the face or tongue, intense pruritus or severe skin rash during treatment with ACE inhibitors in the past or if you or a member of your family have experienced similar symptoms in any other circumstances is called angioedema);
if you have a narrowing of the aortic heart valve (aortic stenosis) or cardiogenic shock
(a condition where the heart can not supply the body with enough blood);
if you have very low blood pressure (hypotension);
if you suffer from heart failure as a result of a heart attack;
if you are pregnant after the third month (also preference is to avoid Preterm start early in pregnancy - see section on pregnancy); if you have diabetes or have impaired kidney function and are being treated with a blood pressure lowering drug containing aliskiren;
if you are undergoing dialysis or any other type of blood filtration. Depending on the device used, Prestarium Co Start may not be suitable for you;
if you have kidney problems where your blood supply to your kidneys is reduced (renal artery stenosis).
Warnings and precautions
Talk to your doctor, pharmacist or nurse before taking Prestarium Startup if:
you have hypertrophic cardiomyopathy (a heart muscle disease); you have heart failure;
you have a severe increase in blood pressure (hypertension); you have other heart problems; you have liver problems;
have kidney problems (including kidney transplant);
you have abnormally elevated levels of a hormone called aldosterone in your blood (primary aldosteronism);
have a collagen vascular disease (connective tissue disease), such as systemic lupus erythematosus or scleroderma; you have diabetes;
adhere to a diet with limited intake of salt or use potassium salt substitutes that contain potassium (it is essential that the blood potassium level is well balanced);
you are elderly and your dose should be increased;
take any of the following medicines used to treat high blood pressure:
angiotensin II receptor blockers (ARB) (also known as sartans - for example valsartan, telmisartan, irbesartan), especially if you have kidney problems associated with diabetes;
Your doctor may periodically check renal function, blood pressure and the amount of electrolytes (potassium in your blood).
Seege also the information under the heading "Do not take Prestarium Start-up" is black, because you may be at greater risk for angioedema and this medicine may be less effective in lowering your blood pressure than non-black patients.
Angioedema (a severe allergic reaction with swollen face, lips, tongue or throat accompanied by difficulty in swallowing or breathing) has been reported in patients treated with ACE inhibitors, including perindopril. This may occur at any time during the course of treatment. If you develop such symptoms, you should stop taking Prestarium Co Start and go to the doctor immediately. See also point 4.
Tell your doctor if you think you are pregnant (or may become pregnant) Prestarium Startup is not recommended in the early stages of pregnancy and you should not take it if you are pregnant after 3 months because it can cause serious damage of your baby if used during this period (see pregnancy point).
While you are taking Prestarium Co Start, tell your doctor or health care professional if you: have general anesthesia and / or severe surgery; you have recently had diarrhea or vomiting (you are sick);
you are going to be subjected to a desensitization treatment to reduce the allergic effects to bee or axle stings;
Children and adolescents
Prestarium should not be used in children and adolescents. Other medicines
ephedrine, noradrenaline or adrenaline (medicines used to treat low blood pressure, shock or asthma);
baclofen used to treat muscle stiffness in some diseases such as multiple sclerosis;
some antibiotics such as rifampicin, erythromycin, clarithromycin;
antiepileptics such as carbamazepine, phenobarbital, phenytoin, fos phenytoin, primidone;
itraconazole, ketoconazole (medicines used to treat fungal infections);
alpha-blockers used to treat prostate enlargement such as prorosin,
alfuzosin, doxazosin, tamsulosin, terazosin;
amifostine (used to prevent or reduce undesirable effects caused by other medicines or radiotherapy used to treat cancer);
corticosteroids (used to treat various conditions, including severe asthma and rheumatoid arthritis);
gold salts, especially when given intravenously (used to treat rheumatoid arthritis symptoms);
ritonavir, indinavir, nelfinavir (the so-called protease inhibitors used to treat HIV);
potassium-sparing medicines to be used in the treatment of heart failure: eplerenone and spironolactone at doses between 12.5 mg to 50 mg per day; trimethoprim (for the treatment of infections); estramustine (used to treat cancer);
hypericum perforatum (St. John's Wort - herbal medicine used to treat depression); Prestarium Getting Started with Food and Drinks Point 3.
People who take Prestarium Co. Start should not consume grapefruit juice and grapefruit juice. This is because grapefruit and grapefruit juice can cause an increase in the blood levels of the active ingredient amlodipine, which in turn may lead to an unpredictable increase in the blood pressure lowering effect of Prestarium Co Start.
Pregnancy and breastfeeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.
Tell your doctor if you think you are pregnant (or you may become pregnant). Your doctor will usually advise you to stop taking Prestarium as a pre-pregnancy or as soon as you know that you are pregnant and will advise you on taking Prestarium as soon as you start taking another medicine. Prestarium Start is not recommended in the early stages of pregnancy and should not be given if you are pregnant after 3 months as it can cause serious harm to your baby if used after the third month of pregnancy.
Tell your doctor if you are breast-feeding or intend to breast-feed. Prestarium Start is not recommended for mothers who are breast-feeding and your doctor may choose another treatment for you if you want to breast-feed, especially if your baby is newborn or premature.
Driving and using machines
Preterm Start-up may affect your ability to drive and use machines. If your tablets make you feel sick, dizzy, faint or tired or if you are having a headache, do not drive or operate machinery and contact your doctor immediately.
Prestarium Start contains lactose monohydrate
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
3. How to take Prestarium Startup
Always take Prestarium What you start exactly as your doctor told you. If you are not sure, ask your doctor or pharmacist.
The recommended dose is one Prestarium 3.5 mg / 2.5 mg once daily tablet.
If you suffer from moderate kidney problems, your doctor may advise you to take one Prestarium 3.5 mg / 2.5 mg tablet every other day at the start of treatment.
Depending on your response to treatment, your doctor may decide to increase the dose of Prestarium Co-Start after one month to 7 mg / 5 mg once a day. The maximum recommended dose of Prestarium High Pressure Start is 7 mg / 5 mg once a day. It is preferable to take your tablet at the same time each morning before a meal. Do not exceed the prescribed dose.
If you take more than the required dose of Prestarium Startup
If you take too many tablets, contact your nearest emergency center immediately or tell your doctor. The most likely response to overdose is low blood pressure, which may cause dizziness or fainting. If this happens, you may find it helpful if you lie down and raise your legs up.
If you forget to take Prestarium Startup
It is important to take your medicine every day, as regular treatment is more effective. However, if you have forgotten to take a dose of Prestarium Co Start, take the next dose at the usual time. Do not take a double dose to make up for the missed dose.
If you stop taking Prestarium Co Start
Because Treatment with Prestarium Co. Start
Common side effects (may affect up to 1 in 10 people): headache, somnolence (especially at the beginning of treatment), abnormal tingling sensation, tingling or aching sensation in the extremities, dizziness, visual disturbances (including double vision) palpitations (feeling palpitations), flushing, shortness of breath (dyspnoea), abdominal pain, nausea (feeling sick), vomiting, dyspepsia or difficulty in digestion, constipation, diarrhea, itching, skin rashes, flushing of the skin, pruritus, swelling of the skin Enita, muscle cramps, fatigue, weakness.
Uncommon side effects (may affect up to 1 in 100 people): increased white blood cell count (eosinophilia), low sodium levels in the blood (hyponatraemia), low blood sugar (hypoglycaemia), mood swings, anxiety , sleeplessness, depression, sleep disturbances, syncope, loss of pain, tremor, vasculitis (inflammation of the blood vessels), rhinitis (stuffy nose or runny nose), abnormal rhythm, dry mouth, increased sweating, hair loss, on the skin, altered skin color, formation of grouped blurred skin, light sensitivity, back pain, muscle or joint pain, urinary tract disorder, increased need for urination at night, increased urination, kidney problems, impotence, discomfort or breast enlargement in men, chest pain , general feeling of being unwell, pain, weight increase or decrease, increased blood urea, increased creatinine in the blood, falls.
Rare side effects (may affect up to 1 in 1,000 people): confusion, high serum bilirubin levels, elevated liver enzymes.
Very rare side effects (may affect up to 1 in 10,000 people): changes in blood counts such as a lower number of white and red blood cells, decreased hemoglobin, fewer platelets, increased muscle tension, nerve disorders, (gingivitis), yellowing of the skin (jaundice), acute renal insufficiency (erectile dyspnoea), anaphylactic shock (a rare type of pneumonia), swelling of the gums. - Patients taking amlodipine also reported the following side effects: a combination of rigidity, tremor and / or movement disturbances.
How To Store Prestarium Startup
Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the carton and the bottle. The expiry date refers to the last day of that month.
This medicine does not require any special storage conditions.
After opening, Prestarium should be used within 10 days for 10 tablet tablets, 30 days for 30 tablet tablets, 50 days for 50 tablet tablets, and 90 days for packs of tablets of 100 tablets.
Do not dispose of medicines in the sewer or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What Contains Prestarium Start Start:
The active substances are perindopril arginine and amlodipine. One Prestarium 3.5 mg / 2.5 mg tablet contains 2.378 mg perindopril equivalent to 3.5 mg perindopril arginine and 3.4675 mg amlodipine besilate equivalent to 2.5 mg amlodipine. One Prestarium 7 mg / 5 mg tablet contains 4,756 mg perindopril equivalent to 7 mg perindopril arginine and 6,935 mg amlodipine besylate equivalent to 5 mg amlodipine.
The other ingredients are: lactose monohydrate, magnesium stearate (E470B), microcrystalline cellulose (E460), anhydrous colloidal silicon dioxide (E551).
How Staggering Prestarium Start & What Contains Packaging:
Prestarium Start 3.5 mg / 2.5 mg tablets are white round tablets with a diameter of 5 mm. Prestarium Co Start 7 mg / 5 mg tablets are white round tablets 6 mm in diameter on the front of which is engraved.
The Prestarium 3.5 mg / 2.5 mg and Prestarium 7 mg / 5 mg Prestarium Start Tablets are available in packs of 10, 30, 60 (2 packs for 30 tablets), 90 (3 packs for 30 tablets tablets), 100 (2 tablets for 50 tablets), 100 or 500 (5 tablets for 100 tablets) tablets.
The desiccant is in the closure of the tablet packs. Not all pack sizes may be marketed
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