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What is Zofran and what is it used for?
Zofran belongs to a group of medicines called antiemetics. Zofran is used to prevent nausea and vomiting that may occur:
• during cancer treatment (chemotherapy or radiotherapy)
• after surgery under general anesthesia.
2. What do you need to know before taking Zofran?
Do not take Zophran
• if you are taking apomorphine (used to treat Parkinson's disease)
• if you are allergic (hypersensitive) to ondansetron or any of the other ingredients of Zofran (listed in section 6)
If you think this applies to you, do not take Zofran before consulting your doctor.
Warnings and precautions
Before you are given Zofran, your doctor needs to know:
• if you are allergic to medicines similar to Zeffran, for example medicines containing granisetron shilonosetron
• if you have ever had heart problems
• if you have heart problems (eg irregular heartbeat or congestive heart failure)
• if you have intestinal problems
• if you have liver disease, your doctor may reduce your dose.
• if you have problems with salt levels in your blood, such as potassium, sodium and magnesium
Talk to your doctor if you think any of the above may apply to you.
Other drugs and Zofran
Please tell your doctor, pharmacist or nurse if you are taking, have recently taken or are taking other medicines, including medicines obtained without a prescription.
In particular, tell your doctor, pharmacist or nurse if you are taking any of the following medicines:
• carbamazepine or feytoin (used to treat epilepsy)
• rifampicin (used to treat infections such as tuberculosis (TB))
• antiarrhythmic drugs, such as amiodarone, used to treat irregular heart rhythm
• medicines called beta-blockers, such as atenolol or timolol, that are used to treat certain heart or eye diseases, anxiety or to prevent migraine attacks
• tramadol (pain reliever)
• medicines that prolong the so-called QT interval (such as haloperidol or methadone)
• antibiotics used to treat infections (such as erythromycin or ketoconazole)
• anticancer medicines (in particular anthracyclines such as doxorubicin or daunorubicin or trastuzumab)
• selective serotonin re-uptake inhibitors (SSRIs) used to treat depression and / or anxiety, including fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram
• SNRs used to treat depression and / or anxiety, including venlafaxine, duloxetine
Tell your doctor or pharmacist if you are taking any of the above.
Pregnancy and breastfeeding
Zofran is not recommended for use during pregnancy.
• Tell your doctor if you are pregnant or are planning to become pregnant.
• If you become pregnant during treatment with Zofran, tell your doctor.
It is not recommended to breast-feed during treatment with Zofran. Zofran's ingredients can pass into breast milk and affect your baby. Discuss this with your doctor.
Zofran tablets contain lactose.
If you have been told by your doctor that you have an intolerance to some sugars, talk to your doctor before taking this medicine.
3. How to take Zofran What dose should you take?
Always take Zofran exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.
To prevent nausea and vomiting after cancer treatment
On the day of treatment:
The usual dose for adults is 8 mg, taken one to two hours before treatment and twelve hours later.
In the next few days:
The usual dose for adults is 8 mg twice daily for up to five days.
Children> 6 months and adolescents:
Your doctor will evaluate the correct dose of Zofran for your child. The usual dose is up to 8 mg daily (up to 4 mg twice a day) for up to five days.
To prevent nausea and vomiting after surgery
The usual dose for adults is 16 mg one hour before surgery.
Children aged> 1 month and adolescents
Zofran tablets are not recommended. Zofran can be given as an intravenous injection.
How to take Zofran?
Swallow the tablets whole with a little water.
Tell your doctor or nurse if you continue to nause yourself.
If you forget to take Zofran
Take the missed dose as soon as possible and then take the next dose at the usual time. Do not take a double dose to make up for the missed dose.
If you are not sure what to do, ask your doctor or pharmacist.
If you take more Zofran than you should
If you inadvertently take more Zofran tablets, it is unlikely to cause you problems, but if you are worried or not feeling well:
Possible side effects
Like all medicines, Zofran can cause side effects, although not everyone gets them.
Severe allergic reactions: These are rare in people taking Zofran. Signs include:
• raised and itchy rash (urticaria)
• swelling, sometimes on the face or mouth (angioedema), which causes difficulty in breathing
Contact a doctor immediately if you experience these symptoms. Stop taking Zofran.
Very common side effects:
They may affect more than 1 in 10 patients:
Common side effects:
They may affect up to 1 in 10 patients:
• a feeling of warmth or redness
Uncommon side effects:
They may affect up to 1 in 100 patients:
• involuntary muscular movements or cramps
• irregular heartbeat
• chest pain
• low blood pressure
Uncommon side effects that may be due to blood tests:
• Enhancement of substances (enzymes) produced by the liver.
Rare side effects
They may affect up to 1 in 1,000 patients:
• severe allergic reactions
• disturbance of heart rhythm (which sometimes leads to sudden loss of consciousness)
• temporarily blurred or disturbed vision.
Very rare side effects
They may affect up to 1 in 10,000 patients:
• Excessive blistering and skin blistering of a large part of the body surface (toxin epidermal necrolysis)
• temporary blindness.
If any of the side effects gets serious or troublesome, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
5. How to store Zofran?
Keep out of the reach and sight of children.
Do not use Zofran after the expiry date which is stated on the pack.
Store below 30 ° C.
Do not dispose of medicines in the sewers or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What does Zofran contain?
The active substance is ondansetron. Each tablet contains 4 mg or 8 mg ondansetron as hydrochloride dihydrate.
The other ingredients are: lactose, anhydrous, microcrystalline cellulose, pregelatinized maize starch, magnesium stearate, methylhydroxypropylcellulose, pericardium yellow M 1-8429 (contains titanium dioxide (E171) and iron oxide (E172)
What does Zofran look like and what does the package contain?
Tablets containing 4 mg ondansetron are yellow in color, elliptical, biconvex, "GXET3" on one side and smooth on the other.
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