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What is Aciclovir AL and what is it used for?
Aciclovir AL is a medicinal product for the treatment of viral infections (antiviral medicine).
Acyclovir AL is used to:
Treatment of shingles
Aciclovir AL is not recommended for the treatment of herpes simplex, viral infections in neonates and severe herpes simplex infection in immunocompromised children.
2. What should you know before you take Aciclovir AL?
Do not take Aciclovir AL:
if you are allergic to aciclovir or valaciclovir or to any of the other ingredients of the medicine (listed in section 6).
Warnings and precautions
Talk to your doctor or pharmacist before taking Aciclovir AL.
If you have deviations in kidney function, a dose adjustment is necessary. Elderly individuals more often have a renal function deviation. Your doctor should regularly monitor renal function.
If you have abnormal kidney function or decreased urine production, you should not use aciclovir for prophylaxis.
If you take high doses of Aciclovir AL - in this case, you should take more fluids.
If you have severe immune deficiency and are being treated for a long time or several times with aciclovir. In this case there is a risk of developing aciclovir-resistant types of herpes simplex virus. Your doctor should carefully monitor your condition.
Other Drugs and Aciclovir AL
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. The effect of Aciclovir AL may be affected by concomitant administration with:
• Probenecid (a medicine used to lower uric acid in the blood)
• Cimetidine (a medicine used to reduce the secretion of gastric juice).
• mycophenolate mofetil (a medicine that suppresses normal immune functions of the body in transplant patients)
• Theophylline (used to treat asthma). However, dose adjustment is not necessary.
Pregnancy, breastfeeding and fertility
If you are pregnant or are breast-feeding, think you may be pregnant or plan to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.
Aciclovir AL should be taken with caution during pregnancy. Do not take Aciclovir AL if you are pregnant, think you may be pregnant or planning a pregnancy before consulting your doctor.
Aciclovir passes into breast milk. Therefore, breast-feeding should be discontinued while receiving aciclovir tablets. If you are breast-feeding or intend to breast-feed, ask your doctor for advice.
Driving with machines
Aciclovir AL may cause side effects that may impair the ability to drive. You should not drive or use machines if you are not sure whether you have any of these side effects.
3. How to take Aciclovir AL?
Always take this medicine exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.
For herpes zoster: 800 mg aciclovir AL 5 times a day (corresponding to 4000 mg aciclovir / day) every 4 hours during the day.
The likelihood of a renal function decline in elderly patients is greater. The doctor should adjust the dose and allow patients to take enough fluids, especially when taking high doses of Aciclovir Al tablets.
Patients with renal impairment:
Patients with abnormal kidney function need a reduced dosage. In case of abnormal renal function, the treating physician will determine the appropriate disposition.
Method of treatment
Tablets should be taken as whole (uncooked) after a meal with a sufficient amount of liquid (eg a glass of water)
Increased fluid levels should be taken with the use of Aciclovir AL tablets, especially in patients with impaired renal function.
Start of treatment:
In order to achieve good results, treatment with Aciclovir AL should begin immediately with the onset of the first symptoms of infection.
Duration of treatment
Herpes zoster infection
The duration of treatment will be determined by your doctor.
The duration of treatment with Aciclovir AL is usually 7-10 days and depends on whether the patient has been successfully cured.
Prevention of herpes simplex virus infections in patients with suppressed immune system
The duration of treatment depends on the degree of immune suppression, the risk of disease, and should be determined individually by the treating physician.
If you take more Aciclovir ALL than you should
Single acute overdosage of Aciclovir AL should not result in serious problems or poisoning. In case of repeated overdosage and worsening of undesirable effects or in case of doubt, talk to your doctor immediately.
If you forget to take Aciclovir AL
Continue treatment as it is before
Possible side effects
Like other medicines, aciclovir AL can cause side effects, although not everyone gets them.
If you experience one or more of the following symptoms of a severe allergic reaction, you should stop taking Aciclovir AL and contact your doctor immediately or go to the nearest Emergency Medical Service:
• Sudden onset of difficulty breathing, talking or swallowing, dyspnoea
• Tiredness, low blood pressure
• Swelling of the lips, tongue, face and throat. Severe allergic reactions (anaphylaxis, angioedema, dyspnoea) are rare.
If any of the following symptoms (affecting the nervous system) appear, you should stop taking Aciclovir AL and contact your doctor or go to the nearest Emergency Medical Service:
Agitation, confusion, tremor, difficulty in coordination of movements and speech disorders (dysarthria), hallucinations, depersonalisation (feeling out of reality, seizures), encephalopathy (cerebrovascular disease), somnolence disturbances of consciousness, of unconsciousness (or coma).
These side effects are reversible and have been reported more frequently in patients with impaired renal function or other predisposing factors and are classified as very rare.
In addition to those listed above, the following side effects are observed:
Common: may affect 1 in 10 individuals
• Skin reactions such as itching, rashes and increased sensitivity to sunlight
• Gastrointestinal disorders such as nausea, vomiting, diarrhea and abdominal pain
• Dizziness, headache
Uncommon: may affect 1 in 100 individuals
• Exhaustion, fever
• Hives (urticaria)
• Increased diffuse hair loss (the association with aciclovir is not well established)
Rare: may affect 1 in 1000 individuals
• Increased blood counts (Blood tests showing changes in liver, kidney function, changes in bile pigment values and urea)
Very rare: may affect between 1 and 10,000 individuals
• Inflammation of the liver (hepatitis), jaundice
• Reducing the number of red blood cells, resulting in pale skin, tiredness or shortness of breath; decreased number of platelets, which increases the risk of bleeding or bruising; decreases the number of white blood cells, which increases the risk of infections
• Acute kidney failure
How to store Aciclovir AL?
Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Do not dispose of medicines in the sewage system or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What Aciclovir AL contains:
Active substance: Aciclovir 1 tablet contains 800 mg acyclovir
The other ingredients are microcrystalline cellulose, copovidone, magnesium stearate, sodium starch glycollate (type A), colloidal anhydrous silica.
What does Aciclovir ALL look like and what does it contain?
White, round, scored tablets on both sides.
Packaging data: Original pack of 35 tablets.
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