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What is Dexamethason KRKA and what it is used.
1 ml of solution for injection (1 ampoule) contains 4 mg of dexamethasone phosphate in the form of sodium salt.
Folding box with 25 ampoules each containing 1 ml of solution for injection (4 mg / 1 ml).
What is Dexamethason KRKA?
Dexamethason is a synthetic corticosteroid. It belongs to the group of the hormones of the adrenal cortex. Natural corticosteroids provide conditions for important life functions and good performance status by maintaining the level of blood glucose, blood pressure and muscle strength and taking part in the control of the balance of sodium, potassium and water in the body, and growth. They also have anti-inflammatory effects, to reduce the activity of the immune system and prevent allergic reactions. Synthetic corticosteroids such as dexamethasone, have the same effect.
What is Dexamethason KRKA?
Dexamethason injection is used in patients for whom treatment with the tablets is not possible, as in the case of emergency. Apply at:
• Allergic conditions: Harnessing severe allergic conditions that defy conventional treatment in asthma, atopic dermatitis, contact dermatitis, hypersensitivity reactions to drugs, chronic or seasonal allergic rhinitis, and serum sickness.
• Dermatological diseases: dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus and severe erythema multiform (Stevens-Jones).
• Endocrine diseases: primary or secondary adrenocortical insufficiency (optionally drug is hydrocortisone or cortisone; can be used in combination with analogous synthetic mineralocorticoids, if applicable, for infant mineralocorticoid additives is particularly important), adrenal hyperplasia, hypercalcemia associated with nesupurativen cancer and thyroiditis. Gastrointestinal diseases: helping the patient during the critical period of the disease in regional enteritis (Crohn's disease) and ulcerative colitis.
• Hematological diseases: acquired (autoimmune) hemolytic anemia, congenital (eritoidna) hypoplastic anemia (anemia Dayamand-Blekfan), idiopathic thrombocytopenic purpura in adults, aplasia pure red blood cells and certain cases of secondary thrombocytopenia.
• Other: diagnostic testing of adrenocortical hyperfunction, trichinosis with neurologic or myocardial development, tuberculous meningitis with subarachnoid block or impending block when used with appropriate anti-tuberculosis chemotherapy.
• Neoplastic diseases: for palliative management of leukemias and lymphomas.
• Nervous system disease: severe deterioration in multiple sclerosis, cerebral edema associated with primary or metastatic brain tumor, craniotomy, or head injuries.
• Eye diseases: sympathetic ophthalmia, temporal arteritis, uveitis, and ocular inflammation with conditions not suitable for local corticosteroids.
• Renal diseases: to generate diuresis or reducing proteinuria in idiopathic nephrotic syndrome or one caused by lupus erythematosus.
• Respiratory diseases: poisoning beryl, fast-flowing and diffuse pulmonary tuberculosis when used concurrently with appropriate anti-tuberculosis chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis.
• Rheumatic diseases: adjunctive therapy for short-term use (helps the patient in severe episodes or deterioration) in acute gouty arthritis, acute rheumatic endomiokardit, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, including rheumatoid arthritis in young people (in some cases can require maintenance therapy with low doses). For the treatment of dermatomyositis, polymyositis and systemic lupus erythematosus.
2. Before you start taking Dexamethason KKKA
Tell your doctor if you have any chronic disease, metabolic diseases, if you are allergic or if you take other medicines.
Who should not apply Dexamethason KKKA?
The drug should not be used if you are allergic to dexamethasone or any of the other ingredients of the medicine. Except in emergency cases, the drug should not be used in the following cases:
- If you have acute viral, bacterial or systemic infection gybichkova and not treated appropriately.
- If you suffer from the consequences of the action of excessive corticosteroids (syndrome of Cushing)
- If you are vaccinated with live vaccines
- If you are breastfeeding
Precautions and warnings
Before starting treatment with dexamethasone, tell your doctor:
- If you have had severe adverse reactions during treatment with dexamethasone or other corticosteroids:
- If you have chronic renal failure;
- If you have liver cirrhosis or chronic liver inflammation;
- If you have decreased activity of the thyroid gland (hypothyroidism);
- If you are being treated for high artesialno pressure;
- If you are being treated for heart failure;
- If you have recently had a heart attack;
- If you are being treated for diabetes;
- If you are being treated for gastrointestinal chrevcho disease;
- If you are being treated for tuberculosis;
- If you are being treated for epilepsy;
- If you are being treated for occlusion of blood vessels by blood clots (thromboembolism);
- If you are being treated for rapid fatigue of the muscles (myasthenia gravis);
- If you are being treated for glaucoma;
- If you are being treated for mental disorders (psychosis, psychoneuroses);
- If you are pregnant or planning to become pregnant.
Consult your doctor if SLE treatment with dexamethasone show the following effects: fever, nasal discharge, redness of the conjunctiva, headache, dizziness, drowsiness or irritability, pain in muscles and joints, vomiting, weight loss, weakness or seizures.
You should consult with your doctor if during the treatment with dexamethasone get sick and have signs of infection (eg fever, cough, headache, pain in joints and muscles, gastrointestinal disorders or difficulty in urination).
Do not overload the joints in which you receive an injection, while the inflammatory process is active.
If after injection into a joint, it gets sorrows swollen and red, you must consult your doctor.
During treatment with dexamethasone may worsen with you if you are diabetic. In the event of increased thirst, consult your doctor.
Before a live virus vaccine should tell your doctor that treated with dexamethasone. Before applying the inactivated virus vaccine, tell your doctor if you have stopped treatment with dexamethasone at least 14 days prior to vaccination.
If you have not had chickenpox or measles during treatment with dexamethasone should avoid contact with patients with these diseases. If, however, be exposed to these diseases, you should seek medical advice at an early date.
In case of serious injury, illness or surgery during or after treatment with dexamethasone, tell your doctor about your treatment with this drug because it can slow the healing of wounds and fractures.
Before scheduled for allergy skin test, tell your doctor that you are taking dexamethasone.
If your children are treated with dexamethasone must track their growth and development during treatment and discuss it with your doctor.
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
As the safety of administration of dexamethasone during pregnancy has not been established, the possible use during pregnancy will be decided by the doctor.
If you become pregnant during treatment with dexamethasone, consult with your doctor about further treatment as early as possible.
Before your baby out, tell your doctor if you are treated with dexamethasone during pregnancy. Dexamethason is excreted in breast milk and therefore you should stop breast-feeding during treatment.
Driving and using machines
No messages to influence the ability to drive and use machines of this medicine.
What other drugs could interact with Dexamethason KRKA?
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
In particular, you should tell your doctor or pharmacist about the following medicines:
• medicines to reduce pain and lower fever (and aspirin), drugs to treat tuberculosis (rifampicin)
• medicines for the treatment of epilepsy (carbamazepine, phenytoin, phenobarbitone, pimidon)
• drugs for the treatment of breast cancer (aminoglutethimide)
• medicines that reduce nasal congestion (ephedrine)
• drugs for diabetes, drugs in elevated blood pressure,
• medicines to increase the secretion of urine (diuretics)
• medicines to treat infestations with intestinal parasites (albendazole)
• medicines for the treatment of heart failure (digitalis)
• medicines to reduce the acidity of gastric juice (antacids)
• medicines to prevent blood clots,
• medicines for contraception (pill).
3. How to use Dexamethason KKKA?
Dosage and method of administration
Dexamethason injection can be injected into a vein, muscle, joint, around a joint or in some other tissues to be treated.
The recommended average daily starting dose for intravenous or intramuscular administration varies from 0.5 to 9 mg or more, if necessary.
The recommended dose of intraarticular Dexamethason is from 0.4 to 4 mg. The dose depends on the size of the affected joint. In skin diseases using the same dose of Dexamethason as for intra-articular administration.
The recommended dose to be injected into the tissue around the joint is 2 to 6 mg Dexamethason.
The doctor will adjust the dose according to the illness of each patient, the expected duration of treatment, the tolerability of the drug and its response to treatment. Thus, the exact dosage, frequency of administration and duration of treatment is always determined by the physician.
If you feel that the effect of the drug is too strong or too weak, talk to your doctor or pharmacist.
Dosage for children
Upon intramuscular administration the dosage for replacement therapy is 0,02 mg / kg body weight or 0,67 mg / m2 body surface area divided by the S held two days apart; or 0.008 to 0,01 mg / kg of body weight or 0.2 to 0.3 mg / m2 of body surface area per day.
Fellowship indications recommended dose is 0.02 to 0,1 mg / kg body weight or 0.8 to 5 mg / m2 body surface in 12 to 24 hours.
The exact dose and duration of treatment will be determined by the doctor.
If you get more Dexamethason KRKA than necessary.
Overdosing can lead to the onset of a large part of these side effects (see "Side effects"), especially Syndrome Cushing, although they usually occur only after several weeks of administration.
The size of the dose and duration of treatment is determined by the doctor. If signs of an overdose or if you suspect that you get a higher dose of the drug than necessary, consult your doctor.
If you miss a dose Dexamethason KRKA
The doctor will determine the frequency of injection. If for some reason you did not receive the intended injection, tell your doctor as soon as possible.
Risks stopping treatment with Dexamethason KRKA
Discontinuation of treatment at your discretion can be very dangerous. If you stop treatment too early, the disease mozhete deteriorate.
4. Possible side effects
As with all drugs, dexamethasone may also have side effects.
Side effects are mainly associated with prolonged treatment with high doses of dexamethasone. If you experience any of these reactions sarzhete immediately with your doctor:
• a sudden increase in blood pressure, severe headache, vomiting,
• changes in heart rhythm
• bleeding from the gastrointestinal tract (vomiting of blood, black stools)
• abdominal pain,
• sudden severe pain in the limbs or back
• sudden swelling,
• severe mental disorders or personality changes
• sudden infections.
These are serious side effects and therefore need urgent medical attention. If you notice any of the following effects, tell your doctor also:
• muscle weakness,
• petechial hemorrhages in the skin or major bleeding
• excessive hair growth,
• violations of the menstrual cycle,
• slow growth of the child.
These are mild side effects of dexamethasone.
Dexamethason usually causes delay in wound healing, thinning and loss of elasticity of the skin, strips the skin (striae), flushing and increased sweating. After prolonged use appears steroid acne.
More rare side effects include: hypersensitivity reactions, blood clots in the circulatory system, impotence, nausea and weakness.
After prolonged treatment dexamethasone can cause glaucoma, cataract, protrusion of the eyeballs (exophthalmos) or high blood pressure or intraocular.
If you notice any side effects, including those not mentioned in this leaflet, please tell your doctor or pharmacist.
5. Storing Dexamethason KKKA
Do not use after the expiry date stated on the packaging.
Keep out of the reach and sight of children.
Do not store above 25 ° C
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