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Dexamethasone WHAT IS AND WHAT IT IS USED FOR ?
Dexamethasone Sopharma solution for injection contains the active ingredient dexamethasone, which have the properties of glucocorticoid hormones from the adrenal cortex , and has anti-inflammatory , anti-allergic and immunosuppressive effects . Meanwhile affect metabolism of carbohydrates, fats, protein and electrolyte balance.
Dexamethasone was used in all conditions where treatment with glucocorticoids .
Dexamethasone was administered to control the emergency status when glucocorticoid orally impossible:
- Edematous conditions including head trauma , cerebral edema
- Shock if you do not respond to other treatments or signs of adrenal failure
- A short-term treatment of severe allergic reactions and anaphylactoid reactions , asthmatic status, exacerbation of chronic allergic diseases such as serum sickness , asthma
- Having an additional treatment for a short period of time in non-specific inflammatory conditions of the joints and soft tissues.
BEFORE YOU USE DEKSAMETAZIN
Do not use Dexamethasone :
As it is used in the management of life-threatening conditions , contraindication to the use of the product can only be hypersensitive to the active substance or any of the excipients .
In all other cases, relative contraindications include: acute and chronic bacterial infections , acute viral infections , chronic active hepatitis , systemic fungal infections , proven infestations , infection at the injection site , unstable joints , 8 weeks after prophylactic vaccination lymphadenitis after vaccination with BCG vaccine , gastric and intestinal ulcers , uncontrolled high blood pressure , severe heart failure , diabetes mellitus , osteoporosis , mental history , glaucoma .
Pregnancy and lactation
Ask your doctor before taking any medicine .
Dexamethasone can be used during pregnancy only in emergency cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus.
Since corticosteroids are excreted in human milk and may cause adverse reactions in nursing infants, mothers should discontinue breast-feeding during treatment.
DRIVE AND USE MACHINES
Not povliyavav alertness and reactions .
Important information about some of the ingredients of dexamethasone
Medicinal product contains sodium less than 1 mmol / 23 mg / dose , i.e. essentially sodium .
HOW TO USE dexamethasone ?
Administered intravenously , intramuscularly or intra-articularly . The dose is determined by the physician according to the disease and the patient's response .
The initial dose may vary from 0.5 mg to 20 mg daily. Acute life-threatening situations , doses may be higher . Recommended parenteral administration no more than 48-72 hours, then to continue treatment with oral administration.
POSSIBLE SIDE EFFECTS
The following are possible side effects: slow heart rate , elevated blood pressure, ventricular , gastric ulcer or duodenal perforation and bleeding from the stomach or intestine , pancreatitis , nausea, hiccups, reduced tolerance to carbohydrates , the occurrence of latent diabetes mellitus, increased need for insulin or oral antidiabetic agents in patients with diabetes mellitus , increased appetite and weight gain, adrenal insufficiency and pituitary , excessive hair growth , abnormal menstrual cycles , decrease in immunity , dizziness , headache, mental disorders , convulsions, increased intracranial pressure , increased intraocular pressure , increased blood clotting , muscle weakness , delayed wound healing , pinpoint bleeding and flushing, increased sweating , urticaria , acne, retention of sodium and water , loss of potassium and calcium, blood dyscrasia , reactions at the injection site such as redness, swelling , pain .
The active substance is Dexamethasone sodium phosphate, dexamethasone phosphate equivalent to 4 mg in an ampoule of 1 mg and 8 mg per ampoule containing 2 mg injection.
Other ingredients are: propylene glycol , disodium edetate, sodium citrate, sodium hydroxide, water for
DETERMINATION OF METHOD OF APPLICATION:
Intravenous or intramuscular administration :
The injectable solution can be used undiluted or diluted with a solution of sodium chloride or glucose for intravenous administration. Dexamethasone can be added to blood tranfuziya .
The initial dose may vary from 0.5 mg to 20 mg per day depending on the disease . Acute life-threatening situations , doses may be higher . In such cases, you should keep in mind the slower absorption by intramuscular administration . In emergency situations the usual dose is 4 mg Ott 20 mg iv or i.m. This dosage may be repeated to obtain the appropriate response. Thereafter may be administered single doses of 2 to 4 mg as needed. The total daily dose should not exceed 80 mg .
After achieving a sufficient effect condition is maintained by intravenous infusion.
Shock - Typically a dose of 2 to 6 mg / kg intravenously once . It can be repeated at an interval of 2 to 6 hours of intravenous infusion or if the patient's condition does not improve . High doses of dexamethasone are administered to the patient is stabilized , usually no more than 48-72 hours. Treatment may be continued infusion of 3 mg / kg bw for 24 hours.
Brain edema - starting dose is 10 mg iv, followed by 4 mg iv every 6 hours until symptoms subside . The effect generally occurs within the first 12 to 24 hours. After 2 to 4 days the dose should be reduced gradually and stopped for a period of 5-7 days. In patients with unresectable or retsedivirasht brain tumor maintenance therapy of 2 mg 2-3 times daily may be effective.
For severe zhevotozastrashavak cerebral edema apply higher starting dose and then the dose is gradually reduced over the next 7-10 days of intensive treatment and discontinued gradually over a period of 7-10 days.
Application in the joints and soft tissues :
Injection into joints and soft tissues is used as the affected joints , or areas are limited to 1 or 2 areas. The spacing of injection varying from once every 3-5 days to once every 2-3 weeks , depending on the relief of symptoms of the disease.
Recommended single doses are:
- Big joints - of 2 to 4 mg
- Small joints - of 0.8 to 1 mg,
- Bursae - from 2 to 3 mg
- Synovial sheaths - from 0.4 to 1 mg,
- Infiltration of soft tissues - from 2 to 6 mg
- Ganglia - from 1 to 2 mg
Doses for children vary individually. As a rule, is recommended by 200 mg / kg body weight per day .
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