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What Lanvexin is and what it is used for
Lanvexin is an antidepressant that belongs to a group of medicines called serotonin and noradrenaline reuptake inhibitors (SNRIs). This group of medicines is used to treat depression and other conditions such as anxiety disorders. People who are depressed and / or anxious are thought to have lower levels of serotonin and noradrenaline in the brain. It is not entirely clear how antidepressants work, but they can help by raising serotonin and noradrenaline levels in the brain.
Lonvexin is a treatment for adults with depression. Lancexin is also an adult treatment with the following anxiety disorders: generalized anxiety disorder, social anxiety disorder (fear and avoidance of social situations), and panic disorder (panic attacks). Proper treatment of depression or anxiety disorders is important for you to feel better. If it is not treated, your condition may not go away and may become more serious and more difficult to treat.
2. What you need to know before you take Lanvexin
Do not take Lanvexin
if you are allergic to venlafaxine or any of the other ingredients of this medicine (listed in section 6);
if you also take or have taken within the last 14 days any medicines known as irreversible monoamine oxidase inhibitors (MAOIs) used to treat depression or Parkinson's disease. Taking an irreversible MAOI together with Lancexin may cause serious or even life-threatening side effects. You should also wait at least 7 days after stopping taking Lanexin before taking any MAOI (see also section "Other medicines and Lancexin" and information on "Serotonin Syndrome").
Warnings and precautions
Talk to your doctor before taking Lanexin if any of the following applies to you:
If you use other medicines that are taken together with Lancexin may increase the risk of developing serotonin syndrome (see section "Other medicines and Lancexin").
If you have eye problems such as certain types of glaucoma (increased eye pressure).
If you have a history of high blood pressure.
If you have a history of heart problems.
If you have a history of seizures (seizures).
If you have a history of low levels of sodium and blood (hyponatraemia).
If you have a tendency to develop bruising or a tendency to bleed easily (a history of bleeding disorder), or if you are taking other medicines that may increase the risk of bleeding, warfarin (used to prevent thrombus formation).
If you have a history or if someone in your family has had a mania or bipolar disorder (you feel over-excited or euphoric).
If you have a history of aggressive behavior.
During the first few weeks of treatment, Lancexin may cause a feeling of restlessness or an inability to sit comfortably in a sitting or standing position. You should tell your doctor if this happens to you.
Thoughts of suicide and worsening of your depressive or anxiety disorder
If you are depressed and / or have anxiety disorders, you can sometimes have thoughts of being self-inflicted or suicidal. They can be tightened when you start to take antidepressants for the first time because all these drugs take time before they start to work, usually about two weeks, but sometimes longer.
You are more likely to think like this:
If you had any thoughts of committing suicide or self-harm before.
If you are a youth. Information from clinical trials shows an increased risk of suicidal behavior in young people (under 25 years of age) with psychiatric conditions who have been treated with antidepressant.
If you have any thoughts of harming yourself or suicide, contact your doctor or go to hospital immediately.
It may be helpful to tell a relative or close friend that you are depressed or have an anxiety disorder and ask them to read this leaflet. You can ask them to tell you if they think your depression or anxiety is getting worse or if they worry about changes in your behavior.
Dry mouth was reported in 10% of the patients treated with venlafaxine. This can increase the risk of tooth decay (caries). Therefore, you should pay special attention to the hygiene of your teeth.
Your blood sugar levels may change due to the use of Lancexin and a dose adjustment of your diabetes medicines.
Children and adolescents
Lanvexin should not normally be used for children and adolescents under 18 years of age. You should also be aware that patients under 18 have an increased risk of side effects such as suicidal ideation, suicidal thoughts and hostility (mostly aggression, oppositional behavior and anger when taking this class of medicines.) However, your doctor may prescribe Lanvelin for patients under 18 as he or she decides whether or not this is the case
Other medicines and Lancexin
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Do not start or stop taking any medicines, including those bought without a prescription, natural or herbal medicines, before consulting your doctor or pharmacist.
Your doctor will need to decide whether you can take Lanvexin with other medicines such as:
Monoamine oxidase inhibitors (MAOIs) that are used to treat Parkinson's depression or illness should not be taken with Lancexin. Tell your doctor if you have taken any of these medicines in the last 14 days. (MAOI: see section 2 "What you need to know before you take Lanvexin").
Serotonin syndrome: a potentially life-threatening condition or neuroleptic malignant syndrome (NMS) (see section "Possible side effects") may occur with venlafaxine, especially when taken with other medicines.
Examples of such drugs include:
Tryptans (used for migraine);
Other medicines for the treatment of depression, for example selective norepinephrine reuptake inhibitors (SNRJ) and serotonin (SSRIs), tricyclic antidepressants or lithium-containing medicines;
Medicines containing linezolid, which is an antibiotic (used to treat infections);
Drugs containing moclobemide, which is a reversible MAOI (used to treat depression);
Drugs containing sibutramine (used to reduce weight);
Medicines containing tramadol (painkillers);
Products containing St John's wort (also called Hypericum perforatum, a natural or herbal medicine used to treat mild depression);
Products containing tryptophan (used for problems such as sleep and depression);
Antipsychotic medicines (used to treat a disease with symptoms such as hearing, seeing or feeling of non-existent things, false beliefs, unusual suspicion, obscure thoughts and insularity.
Signs and symptoms of serotonin syndrome may include a combination of the following: restlessness, hallucinations, loss of coordination, accelerated cardiac activity, increased body temperature, rapid blood pressure changes, overactive reflexes, diarrhea, coma, nausea, vomiting.
In its worst form, serotonin syndrome may resemble neuroleptic malignant syndrome (NMS). Signs and symptoms of NMS may include a combination of fever, rapid heartbeat, sweating, severe muscle stiffness, confusion, increased muscle enzymes (determined by blood testing).
Tell your doctor immediately or go to the nearest hospital if you think you are receiving serotonin syndrome.
The following medicines may also interact with Lanexin and should be used with caution. It is especially important to tell your doctor or pharmacist if you are taking medicines containing:
Ketoconazole (an antifungal medicine);
Haloperidol or risperidone (for the treatment of psychiatric conditions);
Metoprolol (a beta-blocker for the treatment of high blood pressure and heart problems);
Lanvexin with food, beverages and alcohol
Lancexin should be taken with food (see section 3 "How to take Lanvelin").
You should avoid taking alcohol while taking Lonvelin.
Pregnancy, breastfeeding and fertility
If you are pregnant or breast-feeding, think you may be pregnant or plan to become pregnant, ask your doctor or pharmacist for advice before taking this medicine. You should only use Lanvexin after discussing the potential benefits and potential risks to your unborn child with your doctor.
Make sure your midwife and / or doctor know that you are taking Lanvelin. When taken during pregnancy, medicines such as SSRI could increase the risk of serious babies, known as persistent pulmonary hypertension in the newborn, where the baby's breathing is rapid and it appears to be bluish. These symptoms usually occur during the first 24 hours after birth. If this happens to your baby, you should inform your midwife and / or doctor immediately.
If you take this medicine during pregnancy, besides trouble breathing, your baby may also have symptoms of poor nutrition when born. If after birth your baby has these symptoms and you have concerns, talk to your doctor and / or midwife.
Lanvexin passes into breast milk. There is a risk of having an effect on the baby. Therefore, you should discuss this with your doctor and he / she will decide whether you should stop breast-feeding or stop taking this medicine.
Driving and using machines
Do not drive or use any appliances or machines until you understand how Lanvexin affects you.
Lanvexin contains sugar
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this product.
Lanvexin contains sunset yellow
Take Lanexin at approximately the same time each day either in the morning or in the evening. Capsules should be swallowed whole with liquid and not opened, broken, chewed or dissolve.
Lanvexin should be taken with food.
If you have liver or kidney problems talk to your doctor as your dose of this medicine may need to change.
Do not stop taking this medicine without consulting your doctor (see "If you stop taking Lanexin").
If you take more Lancexin than you should
Call your doctor or pharmacist immediately if you have taken more than the prescribed dose of this medicine prescribed by your doctor.
Symptoms of a possible overdose may include accelerated palpitations, changes in alertness (ranging from somnolence to coma), blurred vision, seizures or seizures and vomiting.
If you forget to take Lanvexin
If you miss a dose, take it as soon as you remember. However, if it is time for the next dose, skip the missed dose and take only a single dose as usual. Do not take a double dose to make up for the forgotten dose. Do not take more than the daily amount of Lancexin given to you in one day.
If you stop taking Lavexin
Do not stop taking your treatment and do not lower the dose without your doctor's advice, even if you feel better. If your doctor thinks you no longer need Lanvexin, he may ask you to slowly lower your dose before stopping treatment altogether. It is known that side effects occur when people stop using this medicine, especially when it stops abruptly or the dose drops too fast. Some patients may experience symptoms such as fatigue, dizziness, dizziness, headache, drowsiness, nightmares, dry mouth, loss of appetite, nausea, diarrhea, nervousness, agitation, confusion, tinnitus, tingling or, rarely, sensations such as electrical shock, weakness, sweating, seizures or flu-like symptoms.
Your doctor will advise you on how to stop stopping treatment with Lancexin. If you experience any of these or other symptoms that worry you, talk to your doctor for further advice.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everyone gets them.
If you experience any of the following, do not take Lanvexin. Immediately tell your doctor or go to the emergency room of the nearest hospital:
Chest tightness, wheezing, difficulty in swallowing or breathing;
Swelling of the face, throat, hands or feet;
Feelings of nervousness or anxiety, dizziness, feeling of throbbing, sudden redness of the skin and / or feeling of warmth;
Severe rash, itching or hives (raised plaques of red or pale skin that often itch);
Signs and symptoms of serotonin syndrome, which may include anxiety, hallucinations, loss of coordination, accelerated heartbeat, increased body temperature, rapid blood pressure changes, overactive reflexes, diarrhea, coma, nausea, vomiting. In its worst form, serotonin syndrome may resemble neuroleptic malignant syndrome (NMS). Signs and symptoms of NMS may include a combination of fever, rapid heartbeat, sweating, severe muscle stiffness, confusion, increased muscle enzymes (determined by blood testing).
Other side effects that you should tell your doctor include:
Cough, wheezing, shortness of breath and fever;
Black (tar stools) or blood in stools;
Yellowing of the skin or eyes, itching or darkening of the urine, which may be symptoms of liver inflammation (hepatitis);
Heart problems such as rapid or irregular heart rhythm, increased blood pressure;
Problems with the eyes like blurred vision, enlarged pupils;
Nervous problems such as dizziness, needle sensations, movement disorders, convulsions or seizures;
Psychiatric problems like hyperactivity and euphoria (you feel unusually excited);
Effects of stopping treatment (see section 3 "How to take Lancexin, If you stop taking Lanexin");
Prolonged bleeding - if you cut or injure yourself, it may take a little longer than usual to stop bleeding.
Do not worry if you notice small white granules in your stools after you take Lanvexin. Inside, Lavexin capsules are microspheres or small white pellets that contain the active substance venlafaxine. These microspheres are released from the capsule in your gastrointestinal tract. When the microspheres pass through your entire gastrointestinal tract, venlafaxine is slowly released. The "sheath" of the microspheres remains undisturbed and eliminated
Common (affects 1 to 10 users in 100):
Confusion, a sense of isolation (or separation) from oneself, lack of orgasm, decreased libido, nervousness, insomnia, pathological dreams;
Drowsiness, tremor, numbness of the limbs, increased muscle tone;
Visual disturbances including blurred vision, enlarged pupils and the ability of the eye to automatically change the focus from distant subjects;
Ringing in the tin (tinnitus);
Increased blood pressure, redness;
Vomiting, constipation, diarrhea;
Increased urinary frequency, difficulty in urine output
Menstrual disorders such as increased bleeding or increased irregular bleeding, abnormal ejaculation / orgasm (male), erectile dysfunction (impotence);
Weakness (asthenia), fatigue, chills;
Uncommon (affecting 1 to 10 users in 1,000):
Hallucinations, feelings of isolation (or separation) from reality, agitation, abnormal orgasm (women), loss of feelings or emotions, feelings of euphoria, gnashing of teeth;
Feeling anxious or unable to sit comfortably in a sitting or upright position, seizures, involuntary muscular movements, disturbed coordination and balance, altered in taste sensations;
Palpitations, feeling dizzy (especially when standing up quickly);
Blood vomiting, black tar stools (faeces) or blood in the stools, which may be a sign of internal haemorrhage;
General swelling of the skin, especially of the face, mouth, tongue, throat or hands and feet, and / or possible rash with hives (hives), sensitivity to sunlight, bruising, rash, abnormal hair loss ;
Unavailability of urine;
Increase weight, weight loss.
Rare (affects 1 to 10 users in 10,000):
Seizures or seizures;
Unable to control urination;
Overactive, skipping thoughts and reduced need for sleep (mania).
Reduced platelet counts in your blood, resulting in an increased risk of bleeding or bleeding blood disorders that can lead to an increased risk of infection;
Swelling of the face or tongue, shortness of breath or difficulty in breathing, often with skin rashes (this can be a serious allergic reaction);
Excessive intake of water (known as the syndrome of insufficient secretion of antidiuretic hormone - CHHAX);
Reduced levels of sodium in the blood;
Thoughts of self-harm or suicide have been reported during venlafaxine therapy or immediately after discontinuation of treatment (see section 2 "What you should know before you take Lanvexin");
Disorientation or confusion, often accompanied by hallucinations (delirium), aggression;
High temperature with rigid muscles, confusion or agitation and sweating or if you experience sudden muscular movements that you can not control can be symptoms of serious conditions known as neuroleptic malignant syndrome; euphoric feelings, drowsiness, constant fast eye movements, clumsiness, restlessness, feeling as if you are drunk, sweating or rigid muscles that are symptoms of serotonin syndrome, stiffness, spasms or involuntary muscular movements;
Severe eye pain and reduced or blurred vision;
Blood pressure lowering, abnormal, accelerated or irregular heartbeat, which can lead to a fall; unexpected bleeding, such as bleeding in the gums, blood in urine or vomiting of blood, or unexpected bruising or breakage of blood vessels (fragile veins);
Cough, wheezing, shortness of breath and fever that are symptoms of lung inflammation associated with increased white blood cells (pulmonary eosinophilia);
Severe abdominal or back pain (which could indicate a serious problem in the intestine, liver or pancreas);
Pruritus, yellowing of the skin or eyes, darkening of urine or flu-like symptoms that are symptoms of liver inflammation (hepatitis), slight changes in liver enzyme levels in the blood;
Skin rash, which can lead to severe stroke and peeling of the skin; itching; slight rash;
Unexplained muscle pain, tenderness or weakness (rhabdomyolysis);
Pathological separation of breast milk.
Lanvexin sometimes causes side effects that you may not notice, such as an increase in blood pressure or abnormal heart rhythm; slight changes in blood levels or liver enzymes, sodium or cholesterol. Less commonly, lavexin may reduce the function of the platelets in your blood, resulting in an increased risk of bleeding or bleeding. Therefore, your doctor may occasionally want to perform blood tests, especially if you have taken Lonxigen for a long time.
How to store Lanvexin
This medicine does not require any special storage conditions.
Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the pack. The expiry date refers to the last day of that month.
Do not dispose of medicines in the sewage system or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What Lanexin contains
The active substance is venlafaxine. One capsule contains 169.7 mg of venlafaxine hydrochloride equivalent to 150 mg of venlafaxine free base.
The other ingredients are:
Content of the capsule:
sugar spheres (contains sucrose);
anhydrous colloidal silicon dioxide.
sodium lauryl sulfate;
sunset yellow FCF (E110);
quinoline yellow (E104);
Patent Blue V (E 131);
titanium dioxide (E171).
What Lancexin looks like and contents of the pack
White to off-white granules in a capsule with an ocher-colored lid and a transparent body.
Prolonged-release capsules are available in packs containing 20, 28, 30, 50, 56, 60, 98 and 100 prolonged-release capsules packed in PVC / aluminum blisters. They are also available in HDPE bottles containing 50 and 100 prolonged-release hard capsules.
20, 28, 30, 50, 56, 60, 98 and 100 capsules packed in blisters (PVC / Aluminum).
50 and 100 capsules in a HDPE bottle with a HDPE screw cap and a silica gel sachet (desiccant).
Not all pack sizes may be marketed.
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