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What is Penicillin Crystallized TZF and what it is used for
Penicillin Crystallite TZF contains the active substance benzylpenicillin, which is a natural penicillin. Benzylpenicillin is a bactericidal agent against many gram-negative and gram-positive bacteria.
Penicillin Crystallized TZF is indicated for the treatment of the following severe infections caused by benzylpenicillin-susceptible bacteria:
Tonsillitis, pneumonia, bronchitis, pericarditis, chronic endocarditis caused by streptococci (including group A), pneumococci, staphylococci;
Skin and soft tissue infections;
Diphtheria (in combination with an antitoxin);
Acute rheumatic fever caused by streptococcal infection, arthritis;
Acquired or congenital syphilis;
Infections of the genital tract caused by Fusobacterium spp .;
Mushroom poisoning (Amanita phalloides);
Anthrax, Lyme disease, infections due to Clostridium spp. (including tetanus), listeriosis, pasteurellosis, actinomycosis.
2. What you need to know before using Penicillin Crystallized TZF
Do not use Penicillin Crystallized TZF:
if you are allergic (hypersensitive) to penicillin or other beta-lactam antibiotics.
Warnings and precautions
Talk to your doctor before taking this medicine if any of the following applies to you:
Allergic reaction to some antibiotic in the past.
Another allergic reaction in the past. Penicillin hypersensitivity reactions may occur more often in people who are prone to allergic reactions to different substances. These reactions may vary in symptoms and severity, from skin lesions to anaphylactic shock (severe allergic reaction) - see section 4 "Possible side effects".
Diagnosed kidney and / or cardiac disease.
You should contact your doctor immediately if you develop the following symptoms in relation to the use of the medicine:
Severe or prolonged diarrhea during or after penicillin treatment may be a symptom of pseudomembranous colitis, a complication associated with the use of antibiotics; You should not take any medications that inhibit peristalsis or other bruising medicines, but instead contact a doctor who will prescribe appropriate treatment.
New bacterial or fungal infections caused by the growth of resistant bacterial or fungal strains resulting from prolonged use of penicillin, especially in chronically ill patients or in patients with renal impairment; in this case, you should immediately stop taking the antibiotic and contact a doctor.
In patients receiving high doses of penicillin, the physician usually recommends kidney and liver function tests and blood tests.
Other Drugs and Penicillin Crystallize TZF
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
You should tell your doctor, especially if you use any of the following:
Probenecid (a medicine used to treat gout);
Other antibiotics with bacteriostatic action (eg chloramphenicol, erythromycin, sulfonamides);
Oral contraceptives - It is recommended to use an additional non-hormonal contraceptive method during penicillin treatment.
Interaction with the results of laboratory tests
Penicillin Crystallitis may affect the results of a blood test (Cumbs test), especially in patients receiving high doses.
Pregnancy, breastfeeding and fertility
If you are pregnant or are breast-feeding, think you may be pregnant or plan to become pregnant, ask your doctor before taking this medicine.
Penicillin Crystallize TZF can be used during pregnancy if the doctor thinks it is absolutely necessary to use it.
Benzylpenicillin is excreted in small amounts in breast milk and can cause allergy in the infant. Nursing women should be careful during treatment with Penicillin Crystallized TZF.
Driving and using machines
No data are available on the effects of the medicine on the ability to drive and use machines.
Penicillin Crystallized TZF contains potassium
1 000 000 IU of benzylpenicillin potassium contains 63 mg of potassium to be taken into consideration in patients with renal impairment and in patients on a controlled potassium diet. Before you take this medicine, you should tell your doctor that you have been diagnosed with electrolyte imbalance or kidney failure.
How to Use Penicillin Crystallized TZF
Always use Penicillin Crystallized TZF exactly as your doctor has told you. Consult your doctor if you are not sure.
Penicillin Crystallized TZF is administered by a doctor or nurse.
The dose depends on the severity of the infection, the type of the infective agent and the age and weight of the patient.
1 million IU of benzylpenicillin potassium correspond to 600 mg.
The usual dose is 5 million IU every 4 to 6 hours.
In severe infections, a doctor may increase the dose to 20 million IU or more daily.
Children up to 3 years of age: 50,000 to 80,000 IU / kg / day, divided into 2 to 4 doses (every 12-6 hours), intramuscularly or intravenously.
Children aged 3 to 14: 90,000 to 1,200,000 IU / kg / day, divided into 2 to 4 doses (every 12-6 hours), intramuscularly or intravenously.
Children with fever and fetishes: 250,000 IU / kg / day, divided into 4 to 6 doses, intravenously.
If during the use of this medicine you feel that its effect is too weak or too strong for you, talk to your doctor.
Dosage in patients with renal impairment
For dose changes in this patient group, see information for medical professionals only at the end of the leaflet.
Duration of treatment
The duration of treatment depends on the type and severity of the infection.
The doctor will determine the appropriate duration of treatment to be followed.
Benzylpenicillin can be given as an intramuscular or intravenous injection or by intravenous infusion.
Detailed information on how this medicine is to be used and how the solution is prepared is provided at the end of this leaflet after "The information below is for medical specialists only".
If you take more Penicillin Crystallized TZF than you should
Since Penicillin Crystallized TZF will be given to you by a doctor or nurse, administration of an inappropriate dose is very unlikely. However, if you think you have been given a higher dose of the medicine, you should immediately inform your doctor or go to the emergency room of the nearest hospital.
If you forget to use Penicillin Crystallized TZF
Do not take a double dose to make up for the missed dose.
If you stop using Penicillin Crystallized TZF
It is important to use this medicine in accordance with the recommended treatment cycle. You should not stop treatment simply because you feel better. If the treatment cycle is prematurely terminated, the infection may recur.
If you feel unwell during treatment or are not feeling well after the recommended treatment cycle, you should consult your doctor.
If you have any further questions on the use of this medicine, ask your doctor.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everyone gets them.
The following convention is used to classify the side effects that occurred after the use of this medicine:
very common - occurring in more than 1 in 10 patients;
common - occurring in 1 to 10 patients in 100;
uncommon - occurring in 1 to 10 patients in 1,000;
rare - occurring in 1 to 10 patients in 10,000;
very rare - occurring in less than 1 in 10,000 patients;
not known - can not be estimated from the available data.
Serious side effects
The following side effects are very rare:
sudden difficulty in breathing, talking and swallowing;
painful swelling of the lips, tongue, face or neck;
very strong vertigo or collapse;
severe or itchy skin rashes, especially blistering and pain in the eyes, oral cavity or genital organs.
The following side effects occur with an unknown frequency:
severe, prolonged or bloody diarrhea: it may be a symptom of pseudomembranous colitis.
If any of the serious side effects listed above occur, you should immediately consult your doctor or go directly to the hospital.
The following undesirable effects occur uncommonly:
skin rashes, urticaria, pruritus.
The following side effects are rare:
decreased red blood cell count, white blood cells and platelets (increased bleeding, bruising or infections), abnormal destruction of red blood cells (haemolytic anemia).
The following side effects are very rare:
disturbed heart rhythm;
renal dysfunction (predominantly in patients receiving high intravenous doses of the drug or in patients with pre-existing renal dysfunction).
The following side effects occur with an unknown frequency:
Jarish-Herxheimer's reaction may develop in patients in the course of treatment of syphilis; its symptoms are fever, malaise and headache;
candidiasis (fungal infection) of the skin and mucous membranes;
hyperactivity, agitation, anxiety, drowsiness, confusion, dizziness
How to Keep Penicillin Crystallized TZF
Keep out of the reach and sight of children.
Store below 25 ° C. Keep away from light.
Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date refers to the last day of that month.
Do not dispose of medicines in the sewer or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Package Contents and Additional Information
What contains Penicillin Crystallized TZF
The active substance is benzylpenicillin in the form of benzylpenicillin potassium.
Penicillin Crystallized TZF 1 000 000 IU: one vial contains 1 000 000 IU benzylpenicillin potassium.
Penicillin Crystallized TZF 5,000,000 IU: One vial contains 5,000,000 IU of benzylpenicillin potassium.
This medicine does not contain any other ingredients.
What Penicillin Crystallized TZF looks like and what the package contains
White or almost white, crystalline powder.
Packing: 1 vial in cardboard box.
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