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What is Rabioxin and what is it used for
Rabioxin belongs to a group of medicines called proton pump inhibitors.
Rabioxin acts by inhibiting the production of stomach acid. This prevents irritation of the gastric mucosa so that the gastric ulcer can heal. This relieves pain and discomfort caused by gastric ulcers.
Rabioxin is used for:
benign stomach ulcers
pain or discomfort caused by the passage of stomach acid back up the esophagus (a tubular organ that connects the mouth to the stomach). This effect can cause irritation of the esophagus, causing burning (heartburn) and other symptoms.
as soon as symptoms disappear, rabioxin can also be used to prevent recurrence of the disease
destruction of Helicobacter pylori (gastric infectious bacterium) in patients with benign gastric ulcers (peptic ulcers) in combination with antibiotics
Zollinger-Ellison syndrome (a disorder that causes tumors in the pancreas and duodenum and ulcers of the stomach and duodenum)
If you are not feeling better or your condition is getting worse, you should seek medical attention.
2. What you need to know before taking Rabioxin
Do not take Rabioxin:
if you are allergic to rabeprazole or any of the other medicines (listed in section 6).
if you are pregnant, plan to become pregnant or breast-feeding Warnings and precautions
Talk to your doctor or pharmacist before taking Rabioxin.
if you are allergic to other proton pump inhibitors or "substituted benzimidazoles" (eg pantoprazole, lansoprazole, omeprazole, esomeprazole)
if you suffer from severe liver disease
if you are taking atazanavir (a medicine used to treat HIV; see section 2, Other medicines and Rabioxin)
if you are taking a medicine called methotrexate, it may prolong the serum levels of methotrexate, it may prolong the serum levels of methotrexate and / or its metabolites.
if you have a tumor in your stomach or esophagus. Your doctor may carry out specific tests to rule out cancer before starting treatment with rabeprazole.
if you are on long-term treatment with rabeprazole and are taking medicines such as digoxin (used to treat heart problems) or drainage tablets such as furosemide, spironolactone, hydrochlorothiazide (used to treat high blood pressure or heart problems). In such cases, your doctor may carry out frequent examinations during treatment with rabeprazole.
if you have reduced body supplies or risk factors for a decrease in vitamin B12 and you are on continuous treatment with rabeprazole, as with all acid reducing agents, rabeprazole may lead to decreased absorption of vitamin B12.
have you ever received a skin reaction after treatment with a medicine similar to rabioxin, which reduces stomach acid.
If you get a skin rash, especially in areas exposed to the sun, tell your doctor as soon as possible as you may need to stop treatment with Rabioxin. Be sure to also mention any other adverse effects, such as joint pain.
If you need to do some kind of blood test (Chromogranin A).
Talk to your doctor or pharmacist if:
you experience severe persistent diarrhea (watery or bloody) with symptoms such as fever, abdominal pain or sensitivity, as rabeprazole is associated with a mildly increased incidence of infectious diarrhea.
you suffer from a decrease in a particular type of blood cell with symptoms such as more common infections (such as sore throat and mouth ulcers) and fever, easily bleeding or bleeding.
The use of proton pump inhibitors such as Rabioxin, especially when used for more than 1 year, can moderately increase the risk of hip, wrist or spine fractures. Tell your doctor if you have osteoporosis or if you are taking corticosteroids (which may increase your risk of osteoporosis).
If you are taking long-term treatment (especially if treated for more than one year) with Rabioxin. You need to be reviewed regularly.
The use of Rabioxin in children is not recommended.
Other medicines and Rabioxin
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Rabioxin may interact with some other medicines, such as the following:
or itraconazole (medicines used to treat fungal diseases)
atazanavir (a medicine »used to treat HIV)
methotrexate (a medicine used for chemotherapy at high doses for the treatment of cancer and inflammatory conditions) - if you take high doses of methotrexate, your doctor may suspend your treatment with rabeprazole.
If you are taking any of the above medicines, your dose may need to be adjusted.
Pregnancy, breastfeeding and fertility
Do not take Rabioxin if you are pregnant, planning a pregnancy or breast-feeding,
Driving and using machines
Rabioxin is not likely to cause impairment of the ability to drive or use machines. If you feel drowsy, do not drive or use machines.
3. How to take Rabioxin
Always take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, ask your doctor or pharmacist.
Taking this medicine
Rabioxin gastro-resistant tablets should not be chewed, split into two or crushed. Whole water should be swallowed whole.
If you take Rabioxin once a day, it is preferable to take it in the morning before breakfast.
For duodenal ulcer and benign stomach ulcers: the recommended dose is 20 mg once a day.
In case of pain or discomfort caused by the passage of stomach acid back up into the esophagus (a tubular organ that connects the mouth to the stomach), this effect can cause irritation of the esophagus, causing burning (heartburn) and other symptoms. In some cases, an active ulcer may be present and in other cases an active ulcer may be missing.
In the presence of an active ulcer: the recommended dose is 20 mg once a day for 4-8 weeks.
In the absence of an active ulcer: the recommended dose is 10 mg once a day. If the symptoms persist after four weeks, your doctor may perform some tests. After the symptoms have resolved, all recurrent symptoms can be controlled by taking 10 mg once a day as needed.
To prevent recurrence of the disease: Your doctor will prescribe you 10 or 20 mg once a day, depending on your individual needs.
To eliminate Helicobactor pylori (a bacterium that causes gastric infection): The following treatment for 7 days is often recommended: Rabioxin 20 mg twice daily + clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily.
For Zollinger-Ellison syndrome: the recommended dose is 60 mg once a day. The dose may be increased to 60 mg twice daily. The single daily dose can be up to 100 mg per day.
Duration of treatment:
For duodenal ulcers: It usually lasts 4 weeks, but then your doctor may decide to continue treatment for another 4 weeks
For benign gastric ulcers: It is usually 6 weeks, but then your doctor may decide to continue treatment for another 6 weeks;
For pain or discomfort caused by passage of stomach acid back up into the esophagus in the presence of an active ulcer: 4-8 weeks.
For pain or discomfort caused by passage of gastric acid back up into the esophagus in the absence of an active ulcer: Usually 4 weeks.
To prevent the disease from recurring: Your doctor will tell you how long you should take the pills.
To remove Helicobacter pylori: Usually 7 days.
For Zollinger-EUison Syndrome: As long as the condition requires.
If you take more Rabioxin than you should
If you accidentally take too many tablets, contact your doctor, pharmacist, or hospital.
If you forget to take Rabioxin
If you forget to take one dose, take it as soon as you remember. If the time for taking the next dose is approaching, you should skip the forgotten dose. Do not take a double dose to make up for a forgotten dose.
If you stop taking Rabioxin
Do not change the dose or stop the treatment without discussing it with your doctor.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
The following side effects are serious. If you experience any of these, contact your doctor or pharmacist immediately:
Uncommon (may affect 1 in 100 people)
Fracture of the hip joint, wrist or spine
Rare (may occur in 1 in 1000 people):
Severe allergic reaction - You may experience sudden itching rash (nettle fever), swelling of the hands, feet, ankles, face, lips, mouth or throat (which can cause difficulty swallowing or difficulty breathing), low blood pressure and you feel that you may be faint.
Increasing infections or fever, such as sore throat or mouth ulcers, which can be caused by a decrease in a certain type of white blood cell
Liver inflammation, which may include symptoms such as yellowing of the skin or eyes, pale stools or stomach pain, patients who have previously had liver problems may receive brain damage and result from liver disease (Liver encephalopathies
Uncommon (may affect 1 in 100 people)
Increased values of liver enzymes
Sleepiness Cramps in the legs
Urinary tract infections
Muscle aches and pains
Bronchitis (inflammation of the respiratory tube)
Sinusitis (sinusitis with symptoms such as severe headache, stuffy nose, cough)
Rare (may affect up to 1 in 1,000 people)
Severe kidney problems (interstitial nephritis). You may excrete little or no urine, have blood in your urine, or experience severe lower back pain.
Loss of appetite (anorexia)
Bleeding or bleeding - easier or without explanation. This may be due to a decrease in a certain type of blood cells called platelets (Thrombocytopenia) Increased white blood cell count, which can be seen from blood tests
Inflammation of the mouth, which includes inflammation of the mouth and lips
Inflammation of the inner lining of the stomach (gastritis)
Very rare (may occur in less than 1 in 10,000 people)
Rash with roundish patches (erythema multiforme)
Frequency not known (cannot be estimated from available data)
Hyponatraemia (low levels of sodium in the blood that can cause fatigue and confusion, muscle tremors, seizures and coma)
Development of mammary glands in men
Swollen ankles, soles, feet
If you have been on Rabioxin for more than three months, your blood magnesium levels may decrease. Low levels of magnesium can manifest as fatigue, involuntary muscle contractions, disorientation, convulsions, dizziness, increased heart rate. If you experience any of these symptoms, please tell your doctor immediately. Low levels of magnesium can also lead to decreased levels of potassium or calcium in the blood. Your doctor may decide to do regular blood tests to monitor your magnesium levels.
A rash that may be accompanied by joint pain
Intestinal inflammation (causing diarrhea)
How to store Rabioxin
Keep out of the reach and sight of children.
Do not use this medicine after the expiry date which is stated on the pack after EXP. The expiry date refers to the last day of that month.
Store below 25 ° C. Store in the original package.
Do not use this medicine if you notice that the package is damaged or the integrity is broken.
Do not dispose of medicines in sewage or household waste. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help to protect the environment.
6. Contents of the pack and other information
What Rabioxin contains
The active substance is rabeprazole sodium.
Each 20 mg gastric resistant tablet contains 20 mg of rabeprazole sodium.
The other ingredients are:
Tablet core: mannitol, heavy magnesium oxide, hydroxyprop and cellulose, magnesium stearate.
Middle layer: ethylcellulose, heavy magnesium oxide.
Tablet coating: hypromellose phthalate, dibutyl sebacate, yellow iron oxide (only in Rabioxin 20 mg gastro-resistant tablets), titanium dioxide, talc.
What Robioxin looks like and contents of the pack
Rabioxin 20 mg gastro-resistant tablets: Yellow, film-coated tablets.
The tablets are supplied in blister packs of 1,5,7,14,15,25,28,30,50, 56,75,98 or 120 tablets.
Not all pack sizes and dosages of tablets can be marketed.
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